Search for dissertations about: "Abeta"

Showing result 6 - 10 of 42 swedish dissertations containing the word Abeta.

  2. 6. Targeted Abeta proteomics - A tool to study the pathogenesis of Alzheimer’s disease

    Author : Erik Portelius; Göteborgs universitet; []
    Keywords : Alzheimer’s disease; Cerebrospinal fluid; Immunoprecipitation; Mass spectrometry; beta-amyloid;

    Abstract : Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder of the central nervous system. Diagnosis and monitoring of sporadic AD has long depended on clinical examination of individuals with end-stage disease. READ MORE

  4. 7. Alzheimer disease associated Abeta and gamma-secretase : mitochondrial localization and involvement in cell death

    Author : Camilla Hansson Petersen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In several neurodegenerative disorders, including Alzheimer disease (AD) and Parkinson disease (PD), protein aggregation is accompanied by mitochondrial dysfunction. An increasing number of proteins found in mitochondria have multiple localizations. READ MORE

  5. 8. Alzheimer's Disease: The role of alpha1-antichymotrypsin-amyloid peptide (Abeta 1-42) interaction in the pathogenesis of Alzheimer's disease

    Author : Yongxin Sun; Lund Obstetrik och gynekologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsykologi; neurophysiology; Neurologi; neuropsychology; Neurology; lipid metabolism.; inflammation; á1-antichymotrypsin; Alzheimer’s disease; amyloid-â peptide;

    Abstract : Alzheimer?s disease (AD) is an age-related, irreversible brain disorder that occurs gradually and results in memory loss, behavioural and personality changes. The disease is characterized by an abnormal accumulation of amyloid-beta (Ab) peptide in the extracellular space and the protein Tau within nerve cells of certain regions of the brain. READ MORE

  6. 9. Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease

    Author : Christina Unger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Abeta; Alzheimer s disease; APP; nAChR; NMDA receptors; synaptophysin; transgenic mice; treatment;

    Abstract : The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid betapeptide (Abeta) in the brain triggers the disruption of neuronal and synaptic function, thereby ultimately leading to neurodegeneration and dementia. Some of the crucial questions are if Abeta has a neuronal function in the brain and how it interacts with the neurotransmitter system in AD. READ MORE

  7. 10. Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol lowering drugs in Alzheimer's disease

    Author : Jin Xiu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Nicotinic acetylcholine receptor; Alzheimer s disease; glia cells; Abeta; cholesterol; cholesterollowering drugs;

    Abstract : Nicotinic acetylcholine receptors (nAChRs) are involved in the regulation of many processes including synapses regeneration, neurotransmission and neuroprotection in the central nervous system (CNS). There is increasing evidence for the disturbances in nAChRs in Alzheimer's disease (AD). READ MORE