Search for dissertations about: "Ablation resistance"

Showing result 1 - 5 of 24 swedish dissertations containing the words Ablation resistance.

  2. 1. Cancer Evolution under Chemotherapy Treatment

    Author : Kaname Uno; Cancercellers evolution; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian cancer; Wilms tumor; chemotherapy resistance; ascites; spheroids; diffuse anaplasia;

    Abstract : Background: Chemotherapy resistance is a critical issue in oncology, being responsible for the majority of deaths in modern cancer care. My PhD work has focused on two cancer types where such drug resistance is a major clinical issue: epithelial ovarian cancer (EOC) and Wilms tumor (WT). READ MORE

  4. 2. The assembly of cytosolic lipid droplets and its effect on insulin sensitivity

    Author : Pontus Boström; Göteborgs universitet; []
    Keywords : diabetes; lipid metabolism; insulin resistance; lipid droplets; ADFP; SNARE;

    Abstract : Accumulation of neutral lipids, in particular triglycerides, in non-adipocytes is highly related to the development of insulin resistance and its consequences, type-2 diabetes and cardiovascular diseases. The accumulation of triglycerides occurs in so-called lipid droplets in the cytosol. READ MORE

  5. 3. Ag2S-Based Flexible Memristors for Neuromorphic Computing

    Author : Yuan Zhu; Zhen Zhang; Qing Cao; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Ag2S film; flexible memristor; resistance switching; CMOS-compatible integration; neuromorphic computing;

    Abstract : Memristive crossbar arrays hold the great promise for fast and energy efficient neuromorphic computing due to their parallel data storage and processing capabilities. As the key component, memristor should achieve stable resistance switching (RS) characteristics with low energy inputs and be compatible with complementary metal–oxide–semiconductor (CMOS) technology. READ MORE

  6. 4. From oncogenic replication stress to drug resistance : F-box proteins as signalling hubs in cancer

    Author : Andrä Brunner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer arises from cells that acquire genetic and epigenetic changes during the course of a, sometimes decades-long, somatic evolutionary process. These changes result in deregulation of a multitude of cellular processes leading to novel capabilities, often referred to as hallmarks of cancer, and a strong selective advantage for these cells albeit at a dramatic cost to the organism as a whole. READ MORE

  7. 5. Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise

    Author : Jeffrey W Ryder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skeletal muscle; glucose transport; GLUT4; hypoxia; exercise; Type II diabetes; MAPK; PPAR[gamma] thiazolidinediones;

    Abstract : Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) were examined in skeletal muscle. READ MORE