Search for dissertations about: "Acetyl CoA carboxylase"
Found 4 swedish dissertations containing the words Acetyl CoA carboxylase.
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1. Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance
Abstract : Type 2 diabetes is characterized by chronic hyperglycemia and develops slowly through stages of early impairments of glucose metabolism. The disease is often associated with obesity, physical inactivity, decreased insulin sensitivity and impaired insulin responsiveness. READ MORE
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2. Molecular mechanisms of estrogen action in relation to metabolic disease
Abstract : Estrogens have multiple effects on the body. Most studied are the effects on female reproduction. In this thesis, we have focused on the metabolic effects of estrogens. Estrogen treatment decreases adipose tissue mass and has anti-diabetic effects in humans and mice. READ MORE
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3. Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
Abstract : Type 2 diabetes (T2D) is a heterogeneous disease characterized by altered lipid parameters and elevated glucose levels, as a direct consequence of impaired insulin signaling in target tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is associated with insulin resistance and T2D. READ MORE
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4. Skeletal muscle metabolic flexibility : the roles of AMP-activated protein kinase and calcineurin
Abstract : Skeletal muscle fibers differ considerably in their metabolic and physiological properties. The metabolic properties of skeletal muscle display a high degree of flexibility which adapts to various physiological demands by shifting energy substrate metabolism. READ MORE