Search for dissertations about: "AcrAB"

Found 4 swedish dissertations containing the word AcrAB.

  1. 1. Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marius Linkevičius; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Tigecycline; Bacterial resistance; Fitness; Escherichia coli; AcrAB; LPS; Tet proteins; Tet A ; Tet K ; Tet M ; Tet X ; tet genes; pUUH239.2; Mikrobiologi; Microbiology;

    Abstract : Antibiotic resistance is an ongoing global medical crisis and we are in great need of new antibacterial agents to combat rapidly emerging resistant pathogens. Tigecycline is one of few drugs that have been introduced into medicine during the last two decades. READ MORE

  2. 2. Antibiotic resistance in Gram-negative bacilli : With focus on cephalosporin resistance mechanisms in Escherichia coli and Klebsiella pneumoniae

    University dissertation from Stockholm : Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology

    Author : Owe Källman; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Objectives. The objectives of this thesis were to study mechanisms conferring cefuroxime resistance in clinical non-ESBL (extended-spectrum beta-lactamase) producing isolates of Escherichia coli and Klebsiella pneumoniae, as well as the presence of co-resistance to other antibiotics in the K. pneumoniae isolates. READ MORE

  3. 3. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lisa Praski Alzrigat; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

    Abstract : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. READ MORE

  4. 4. Borrelia channel-forming proteins structure and function

    University dissertation from Umeå : Umeå University

    Author : Ignas Bunikis; Umeå universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Borrelia; Lume disease; relapsing fever; BesC; drug efflux; DipA; P66; porins; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Molecular biology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Borrelia is a Gram-negative, corkscrew-shaped bacterium transmitted by infected ticks or lice. Borreliae are subdivided into pathogens of two diseases: Lyme disease, caused mainly by B. burgdorferi, B. afzelii and B. READ MORE