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Showing result 1 - 5 of 24 swedish dissertations matching the above criteria.

  2. 1. Profilin:actin in cell motility : A search for profilin:actin binding proteins

    Author : Thomas Johansson; Roger Karlsson; Björn Öbrink; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; profilin; actin; Cell biology; Cellbiologi;

    Abstract : The profilin:actin complex is a major source of actin for actin filament growth in vivo. A number of proteins regulating either profilin or actin has been described since profilin:actin was isolated during the 1970s. Since then, profilin and actin and their binding partners have been intensively studied. READ MORE

  4. 2. Divisive structures : Two billions years of biofilament evolution

    Author : Fredrik Hurtig; Ann-Christin Lindås; Lionel Guy; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Evolution; Archaea; Eukaryogenesis; ESCRT-III; Actin; Profilin; Gelsolin; Asgard; TACK; Sulfolobus; Cell division; Cytokinesis; Cytoskeleton; Heimdallarchaeota; Actin-binding protein; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Our understanding of the functional and regulatory complexity that existed in the eukaryotic progenitor is poor, and investigations have been hindered by our nebulous understanding of where eukaryotes stem from. Recently discovered archaeal lineages with hitherto unseen homology to eukaryotic systems suggest archaea can further our understanding of the eukaryotic cell’s ancestry. READ MORE

  5. 3. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

    Author : Xianghua Zhou; Göteborgs universitet; []
    Keywords : filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

    Abstract : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. READ MORE

  6. 4. Protein kinase C epsilon and neurite outgrowth

    Author : Ruth Zeidman; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ;

    Abstract : Protein kinase C (PKC) is a serine/threonine kinase family with 10 identified isoforms. The contribution of PKC isoforms to cell growth and differentiation, with focus on neurite outgrowth, was investigated, using neuroblastoma and immortalised neural cells as model systems. READ MORE

  7. 5. Structural Study of the WH2 Family and Filamin: Implications for Actin Cytoskeleton Regulation

    Author : Adeleke H. Aguda; Robert Robinson; Lars Rask; Lars Backman; Uppsala universitet; []
    Keywords : Biochemistry; Actin; Thymosin; Ciboulot; N-WASP; Filamin; Calponin homology domain; WH2; Protein Crystallography; Biokemi;

    Abstract : Cellular processes like motility, chemotaxis, phagocytosis and morphogenesis are dependent on the dynamic regulation of the actin cytoskeleton. This cytoskeleton system is tightly controlled by a number of diverse actin-binding proteins (ABPs) by various mechanisms described as nucleation, polymerization, capping, severing, depolymerization and sequestration. READ MORE