Search for dissertations about: "Acute Lymphoblastic Leukemia"
Showing result 11 - 15 of 80 swedish dissertations containing the words Acute Lymphoblastic Leukemia.
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11. Resolving the Genomic Complexity of Pediatric Acute Lymphoblastic Leukemia
Abstract : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Structural chromosomal rearrangements are a hallmark of ALL and represent key markers for diagnosis, risk stratification and prognosis. READ MORE
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12. IKAROS and LEUKEMIA
Abstract : Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. READ MORE
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13. Molecular Interrogation and Functional Studies of Acute Leukemia
Abstract : Hematological malignancies are defined by their underlying genetic alterations, many of which are used to diagnose patients to classify them to different risk groups that dictate the therapy given. Recent advances in high-throughput sequencing have highlighted the presence of co-occurring genetic lesions and that they may form distinct genetic clones that evolve throughout disease progression. READ MORE
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14. Gene Expression Studies of Hematologic Malignacies
Abstract : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. READ MORE
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15. Vascular density and bone marrow fibrosis in childhood acute lymphoblastic leukemia
Abstract : Background: In childhood acute lymphoblastic leukemia (ALL), the cure rate has now reached 80% in the western world. Even so, 15¬–20% will die from the disease or treatment-related causes, among them children who did not present any known unfavorable features at diagnosis. READ MORE