Search for dissertations about: "Acute leukemia"

Showing result 1 - 5 of 217 swedish dissertations containing the words Acute leukemia.

  1. 1. Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry

    Author : Lovisa Vennström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Acute leukemia; population-based; incidence; survival; acute myeloid leukemia; acute lymphoblastic leukemia; acute promyelocytic leukemia; early death;

    Abstract : Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical and biological features. READ MORE

  2. 2. Epidemiological studies in de novo and secondary acute leukemia

    Author : Erik Hulegårdh; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Acute leukemia; ALL; AML; adult; Secondary acute leukemia; MDS; MPN;

    Abstract : Abstract Background Acute leukemia (AL) is a rare blood cancer with poor prognosis in adult patients. Socioeconomic factors are known to impact cancer outcomes, but have not been adequately examined among adult AL patients. READ MORE

  3. 3. Functional Screens Identify Vulnerabilities in Acute Leukemia

    Author : Ramprasad Ramakrishnan; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; CRISPR; CXCR4; CXCL12; TNFSF13; DUX4; Interleukin 4; leukemia stem cell; macrophage;

    Abstract : Acute leukemia refers to a group of aggressive hematological malignancies of myeloid and lymphoid lineages termed acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) respectively. Acute leukemia is characterized by the presence of underlying genetic aberrations which alter the biology of normal hematopoietic cells resulting in the accumulation of immature abnormally differentiated blast cells. READ MORE

  4. 4. Molecular Interrogation and Functional Studies of Acute Leukemia

    Author : Axel Hyrenius Wittsten; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; KMT2A; Cooperating Lesions; Clonal Relationship; Genomic Profiling; Fusion Genes;

    Abstract : Hematological malignancies are defined by their underlying genetic alterations, many of which are used to diagnose patients to classify them to different risk groups that dictate the therapy given. Recent advances in high-throughput sequencing have highlighted the presence of co-occurring genetic lesions and that they may form distinct genetic clones that evolve throughout disease progression. READ MORE

  5. 5. IKAROS and LEUKEMIA

    Author : Linda Olsson; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatric acute lymphoblastic leukemia; relapse; risk-stratifying factors; IKZF1; cooperative changes;

    Abstract : Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. READ MORE