Search for dissertations about: "Acute lymphoblastic leukemia mercaptopurine"

Found 2 swedish dissertations containing the words Acute lymphoblastic leukemia mercaptopurine.

2. 1. Pharmacological studies on uptake, metabolism, and resistance to anti-cancer drugs : insights into the treatment of leukemia

   Author : Hazhar Karim; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Leukemia is blood cancer that begins in the bone marrow and characterized by abnormal production of white blood cells. Due to advances in treatment, there has been a dramatic increase in survival rate for patients with different types of leukemia. READ MORE

4. 2. Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism

   Author : Anna Zimdahl; Malin Lindqvist Appell; Lars-Göran Mårtensson; Inger Johansson; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The thiopurines (6-mercaptopurine [6-MP], 6-thioguanine and azathioprine) are cytotoxic drugs used in the treatment of acute lymphoblastic leukemia (ALL), inflammatory bowel diseases, certain autoimmune diseases and after transplantation. The metabolism of thiopurines is complex with several enzymes involved in the conversion into active drug metabolites. READ MORE