Search for dissertations about: "Acyl-CoA thioesterase"

Showing result 1 - 5 of 8 swedish dissertations containing the words Acyl-CoA thioesterase.

2. 1. Molecular cloning and characterization of the murine acyl-CoA thioesterase CTE-I

   Author : Per J G Lindquist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Acyl-CoA thioesterase; acyl-CoA; peroxisome proliferator-activated receptor alpha; fatty acid metabolism;

   Abstract : Mouse cytosolic type I acyl-CoA thioesterase (CTE-I) is a member of the type I family of acylCoA thioesterases. These enzymes hydrolyze acyl-CoAs to non-esterified fatty acids (NEFAs) and Coenzyme A (CoA-SH) and are strongly induced in rodent liver by a diverse group of compounds called peroxisome proliferators. READ MORE

4. 2. Acyl-CoA thioesterases : auxiliary enzymes in peroxisomal lipid metabolism

   Author : Maria A K Westin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Peroxisomes are small organelles essential for life, which carry out a variety of functions mostly related to lipid metabolism, including α- and β-oxidation as well as the first steps of plasmalogen biosynthesis. Peroxisomal β-oxidation metabolizes many different lipids including very long-chain fatty acids, dicarboxylic fatty acids, branched-chain fatty acids, eicosanoids and certain xenobiotic fatty acids. READ MORE

5. 3. The type-I acyl-CoA thioesterase/acyltransferase gene family : linking structure to function

   Author : James O'Byrne; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Type-I acyl-CoA thioesterase acyltransferase gene family; structure function relationship; nueleophilic elbow; esterase transferase activity;

   Abstract : Acyl-CoA thioesterases hydrolyse acyl-CoAs to non-esterified fatty acids and coenzyme A (CoASH), thereby regulating intracellular levels of these compounds. We have recently identified and initiated characterisation of a novel, unique gene family of acyl-CoA thioesterases/acyltransferases, called the Type-I acyl-CoA thioesterase/acyltransferase gene family. READ MORE

6. 4. Characterization of peroxisome proliferator-activated receptor alpha (PPARa) regulated acyl-CoA thioesterases involved in lipid metabolism

   Author : Mary C Hunt; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Acyl-CoA thioesterase; acyl-CoA; peroxisome proliferator-activated receptor alpha; coenzyme A; bile acid metabolism; lipid metabolism.;

   Abstract : The peroxisome proliferator-activated receptor alpha (PPARalpha) is a key nuclear receptor in the control of lipid metabolism. Target genes for PPARalpha include many enzymes involved in the oxidation of fatty acids in mitochondria and peroxisomes. READ MORE

7. 5. Functional characterization of a peroxisomal acyltransferase gene family

   Author : Sarah-Jayne Reilly; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Peroxisomes are cell organelles that play an important role in the metabolism of a variety of lipids including very long chain fatty acids, dicarboxylic acids, bile acids, and xenobiotic carboxylic acids. The metabolism of lipids in peroxisomes requires the concerted efforts of many different enzymes, which includes members of the type I acyl-CoA thioesterase/acyltransferase protein family and the nudix hydrolases. READ MORE