Search for dissertations about: "AdCD40L"

Showing result 1 - 5 of 6 swedish dissertations containing the word AdCD40L.

  2. 1. Experimental treatment of patients with disseminated malignant melanoma

    Author : Aglaia Schiza; Gustav Ullenhag; Angelica Loskog; Sara Mangsbo; Thomas Tötterman; Ola Winqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant melanoma; AdCD40L; immunotherapy; proteomics; DW-MRI; FDG-PET CT; prediction; early response; BRAF-inhibitor; vemurafenib; Oncology; Onkologi;

    Abstract : Malignant melanoma (MM) is the deadliest skin cancer with an ever-increasing incidence. New treatments have improved the prognosis for patients with advanced MM. Still, most patients do not respond, and the side effects can be severe, underlining the need for better therapies. READ MORE

  4. 2. CD40L Gene Therapy for Solid Tumors

    Author : Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

    Abstract : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. READ MORE

  5. 3. Immunogene Therapy of Bladder Carcinoma : A Preclinical Study

    Author : Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Immunotherapy; Gene therapy; Immunogene therapy; CD40L; Bladder carcinoma; Onkologi; Oncology; Onkologi; Klinisk immunologi; Clinical Immunology;

    Abstract : This thesis comprises studies on murine and human models of bladder carcinoma with the aim to develop novel immunogene therapies. On the basis of the results presented in this thesis, a clinical trial is underway. The potential of activating the immune system to combat cancer has long intrigued immunologists. READ MORE

  6. 4. Adenovirus-mediated CD40 Ligand Immunotherapy of Prostate and Bladder Cancer

    Author : Helena Dzojic; Magnus Essand; Thomas H Tötterman; Aristides Eliopoulos; Uppsala universitet; []
    Keywords : Medicine; immunotherapy; gene therapy; prostate cancer; bladder cancer; adenoviral vector; CD40 ligand; promoter; PPT; TSTA; depsipeptide FK228; TRAMP-C2; Medicin;

    Abstract : Cancer immunotherapy aims at reversing the immunosuppressive tumor environment and enhancing anti-tumor immunity. This thesis comprises studies on murine models for prostate (TRAMP-C2) and bladder (MB49) cancer with the aim to explore if the introduction of an adenoviral vector expressing CD40 ligand (AdCD40L) can induce anti-tumor immune responses. READ MORE

  7. 5. Intratumoral CD40 stimulating therapy in patients with advanced cancer

    Author : Sandra Irenaeus; Gustav Ullenhag; Angelica S. Loskog; Poulam Patel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40; CD40L; immunotherapy; early clinical studies; advanced cancer; intratumoral administration; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

    Abstract : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. READ MORE