Search for dissertations about: "Adenosine A2A receptor"
Showing result 1 - 5 of 24 swedish dissertations containing the words Adenosine A2A receptor.
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1. Striatal adenosine A2A receptors
Abstract : The nucleoside adenosine exerts a modulatory action in the central nervous system by activating G-protein coupled receptors. Four such receptors are cloned and pharmacologically characterized: A1, A2A, A2B and A3. Caffeine, the most widely consumed psychostimulant, acts as an adenosine receptor antagonist predominantly on the first two. READ MORE
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2. Effects of adenosine and acetylcholine on the lacrimal gland
Abstract : A balanced tear film is essential for a healthy ocular surface. Insufficient tear production may result in dry eye, a common disorder in the elderly population. Dry eye causes significant discomfort in the patients and may lead to visual impairment and ocular infections. READ MORE
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3. Adenosine receptor/dopamine receptor interactions : molecular and biochemical aspects
Abstract : The dopamine receptors have been shown to be involved in a variety of higher brain functions, such as motor control, cognition and affective states. Agonist and antagonists of dopamine receptors are widely used to treat disorders such as Parkinson's disease and schizophrenia, respectively. READ MORE
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4. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction
Abstract : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. READ MORE
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5. Advances in Ligand Binding Predictions using Molecular Dynamics Simulations
Abstract : Biochemical processes all involve associations and dissociations of chemical entities. Understanding these is of substantial importance for many modern pharmaceutical applications. In this thesis, longstanding problems with regard to ligand binding are treated with computational methods, applied to proteins of key pharmaceutical importance. READ MORE