Search for dissertations about: "Adipogenesis"

Showing result 6 - 10 of 34 swedish dissertations containing the word Adipogenesis.

2. 6. Differentiation of Human Dermal Fibroblasts and Applications in Tissue Engineering

   Author : Pehr Sommar; Gunnar Kratz; Thomas Hansson; Anders Lindahl; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue Engineering; Human Dermal Fibroblasts; Differentiation; Adipogenesis; Chondrogenesis; Endotheliogenesis; Osteogenesis; Plastic surgery; Plastikkirurgi;

   Abstract : Tissue engineering applies principles of biology and engineering to the development of functional substitutes for damaged or lost tissues. Tools for the neo-generation of tissue in tissue engineering research include cells, biomaterials and soluble factors. READ MORE

4. 7. Inflammation and impaired adipogenesis in human white adipose tissue

   Author : Juan Ramón Acosta; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : This thesis aimed to study inflammation and adipogenesis capacity in human subcutaneous white adipose tissue with respect to the development of obesity and associated comorbidities, including insulin resistance. Study I showed that the transcription factor, MAFB, was associated with increased adiposity and involved in regulation of TNFα-mediated inflammatory response, yet did not seem to directly influence adipogenesis or metabolism in human adipocytes. READ MORE

5. 8. Molecular Mechanisms of Graves' Ophthalmopathy. A focus on smoking and radioiodine

   Author : Bushra Shahida; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Graves’ disease. Graves’ ophthalmopathy; radioiodine; inflammation; adipogenesis; IL-1ß; IL-6; PTGS2 COX2; PGE2; CTLA-4; B lymphocytes; T lymphocytes; Simvastatin; Diclofenac; SNP; gene expression; IGF-1;

   Abstract : Graves’ disease (GD) is an autoimmune disease characterized by hyperthyroidism and is caused by an interplayof genetic and environmental factors. One-third of patients with GD develop Graves’ ophthalmopathy (GO). Keyprocesses in the pathogenesis of GO are inflammation and adipogenesis in orbital tissue. READ MORE

6. 9. The role of thyroid stimulating hormone receptor and novel candidate genes FAM13a and POM121c in adipocyte dysfunction

   Author : Veroniqa Lundbäck; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : This thesis aimed to investigate the role of thyroid stimulating hormone receptors (TSHRs) in adipose tissue (AT) and their role in AT dysfunction and obesity-related metabolic complications. Furthermore, we aimed to functionally evaluate novel candidate genes associated with insulin resistance, a marker of dysfunctional adipose tissue. READ MORE

7. 10. Impact of epidemiologically identified mixtures of endocrine disrupting chemicals on metabolic programming

   Author : Polina Lizunkova; Joëlle Rüegg; Elin Engdahl; Joachim Sturve; Carl-Gustaf Bornehag; Juliette Legler; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Endocrine disrupting chemicals; Mixtures; Metabolism; Developmental Toxicology; Epigenetics; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

   Abstract : We are ubiquitously exposed to a plethora of endocrine-disrupting chemicals (EDCs), i.e. substances that alter the function(s) of the endocrine system. While ample evidence show individual EDC's influence on developmental processes resulting in adverse health outcomes, less is known about the effects of human-relevant EDC mixtures exposure. READ MORE