Search for dissertations about: "Adjuvant-induced arthritis"

Showing result 1 - 5 of 6 swedish dissertations containing the words Adjuvant-induced arthritis.

  2. 1. Pathogenetic studies of adjuvant-induced arthritis

    Author : Barbro Holm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adjuvant-induced arthritis; squalene; Incomplete Freunds Adjuvant; QTL; lymph nodes; inflammation;

    Abstract : Rheumatoid arthritis (RA) is a disabling chronic inflammatory disease, presumably autoimmune, that progressively destroys peripheral joints. The etiopathogenesis remains largely unknown, and an understanding of disease mechanisms and identification of genes is rendered difficult due to the multifactorial influence on RA. READ MORE

  4. 2. Immunologic and genetic studies of rat adjuvant-induced arthritis

    Author : Åsa Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : arthritis; autoimmunity; adjuvant; incomplete Freund s adjuvant; squalene; quantitative trait locus;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a multifactorial and largely unknown etiology. It is influenced by both environmental and genetic factors, and understanding of disease mechanisms and identification of disease-causing genes is hampered by the complex and polygenic nature of the disease. READ MORE

  5. 3. Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target

    Author : Patrick Leclerc; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2. PGE2 has pro-inflammatory and immunomodulatory functions and is involved in an array of diseases with an autoimmune and chronic inflammatory component, including rheumatoid arthritis (RA). READ MORE

  6. 4. Behavioural and neurochemical effects of long-lasting inflammatory pain

    Author : Umut Heilborn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The treatment of chronic, inflammatory pain in humans is still unsatisfactory. In order to develop new anti-inflammatory and analgesic drugs, studies on the mechanisms underlying inflammatory pain in valid animal models, are of considerable importance. READ MORE

  7. 5. Prostaglandin E2 in immune-to-brain signaling

    Author : David Engblom; Tamas Bartfai; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Upon immune-challenge, signaling from the immune system to the brain triggers an array of central nervous responses that include fever, anorexia, hyperalgesia and activation of the hypothalamus-pituitary adrenal axis. These symptoms are dependent on cytokines produced at the site of inflammation. READ MORE