Search for dissertations about: "Administration Oral"

Showing result 1 - 5 of 189 swedish dissertations containing the words Administration Oral.

  2. 1. Pharmacokinetics of the enantiomers of thalidomide

    Author : Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. READ MORE

  4. 2. Functional Ceramics in Biomedical Applications : On the Use of Ceramics for Controlled Drug Release and Targeted Cell Stimulation

    Author : Johan Forsgren; Håkan Engqvist; Strømme Maria; Susanne Bredenberg; Pentti Tengvall; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Controlled release; geopolymer; sol-gel; opioid; oral administration; oral dosage form; implant; titanium; hydroxyapatite; infection; strontium carbonate; strontium; Functional materials; Funktionella material; Materials science; Teknisk materialvetenskap; Material physics with surface physics; Materialfysik med ytfysik; Teknisk fysik med inriktning mot nanoteknologi och funktionella material; Engineering Science with specialization in Nanotechnology and Functional Materials;

    Abstract : Ceramics are distinguished from metals and polymers by their inorganic nature and lack of metallic properties. They can be highly crystalline to amorphous, and their physical and chemical properties can vary widely. READ MORE

  5. 3. Recurrent Aphthous Stomatitis - A study, with emphasis on host genetics, oral microbiota composition, and immunoregulatory networks

    Author : Maria Bankvall; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aphthous stomatitis; Oral mucosa; Oral medicine; Genome-wide association study; Genetic linkage; Association; Genetic polymorphism; Microbiota; Restriction fragment length polymorphism; Antigen-presenting cell; T-lymphocyte; Lymph node; Flow cytometry;

    Abstract : Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal lesions. The aetiology is unknown and currently there is no consensus regarding suitable treatment regimens. READ MORE

  6. 4. Oral delivery of macromolecules formulated with permeation enhancers

    Author : Staffan Berg; Christel Bergström; Nigel Davies; Andreas Hugerth; David Brayden; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral peptide delivery; permeation enhancer; sodium caprate; oral drug delivery; intestinal absorption of macromolecules; Biofarmaci; Biopharmaceutics; Galenisk farmaci; Pharmaceutics;

    Abstract : Therapeutic macromolecules including peptides, proteins, and nucleotide-based ones (such as antisense oligonucleotides and RNAs) have great potential as drug candidates. One drawback is that they typically need to be administered parenterally via subcutaneous, intramuscular or intravenous injections. READ MORE

  7. 5. Essays on the interaction between regulation and technology : Understanding agency and context through multiple levels of inquiry

    Author : Rasmus Nykvist; Christina Öberg; Mirko Ernkvist; Christian Sandström; Lars Engwall; Örebro universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Institutional Entrepreneurship; Technological Transformation; Regulation; Historical Methods; Stockholm Stock Exchange;

    Abstract : A key challenge for implementing pioneering regulatory and technological change includes overcoming regulatory constraints and resistance from vested interest groups in favor of the status quo. This is a compilation dissertation comprising five papers and one covering paper that aims to describe and explain the interaction between agency and context under conditions of combined technological and regulatory change through multiple levels of inquiry. READ MORE