Search for dissertations about: "Adrenomedullin"

Showing result 6 - 10 of 12 swedish dissertations containing the word Adrenomedullin.

  2. 6. Expression of Neuroendocrine Markers in Normal and Neoplastic Tissue with an Emphasis on Ghrelin and Obestatin

    Author : Malin Grönberg; Eva Tiensuu Janson; Apostolos Tsolakis; Jan Saras; Mauro Papotti; Uppsala universitet; []
    Keywords : ghrelin; obestatin; neuroendocrine marker; immunohistochemistry; neuroendocrine tumors; breast cancer; mammary glands; MEDICINE; MEDICIN; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : The aim of this thesis was to characterize the expression of the peptides ghrelin and obestatin, as well as other neuroendocrine markers in human normal tissues, in invasive breast cancer and a wide panel of neuroendocrine tumors (NETs). In normal tissues the expression of ghrelin and obestatin was mainly localized to the gastric mucosa, and in lesser extent in the remaining gastrointestinal tract, endocrine pancreas and mammary glands. READ MORE

  4. 7. Epidemiological, mechanistic and genetic aspects of vascular ageing and arterial stiffness in the population

    Author : Mikael Gottsäter; Internmedicin - epidemiologi; []
    Keywords : Vascular ageing; Arterial stiffness;

    Abstract : The core feature of vascular ageing is the age-associated stiffening of the large, elastic arteries, or arteriosclerosis. This results in a diminished volume-buffering function and is therefore central for the increase in systolic blood pressure and pulse pressure seen with advancing age. READ MORE

  5. 8. The calcitonin gene family of peptides : receptor expression and effects on bone cells

    Author : Susanne Granholm; Ulf Lerner; Pernilla Lundberg; Göran Andersson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; CT family of peptides; osteoclast differentiation; bone resorption; CTR; CRLR; RAMPs; Cell biology; Cellbiologi;

    Abstract : The calcitonin gene family of peptides consists of calcitonin (CT), two calcitonin gene related peptides (α-CGRP, β-CGRP), adrenomedullin (ADM), amylin (AMY), three calcitonin receptor activating peptides (CRSP1-3) and intermedin/adrenomedullin2 (IMD). These peptides bind to one of two G protein -coupled receptors, the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CRLR). READ MORE

  6. 9. A targeted approach to maintenance of tumour response. Clinical and translational studies in metastatic colorectal cancer

    Author : Helga Hagman; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; kolorektal cancer; underhållsbehandling; biomarkörer; angiogeneshämning;

    Abstract : In metastatic colorectal cancer (mCRC) chemotherapy +/- targeted therapy with palliative intent aims at prolonging survival with sustained quality of life. Maintenance of tumour response by a period of less intense treatment maydelay progression and accumulation of unacceptable toxicity. READ MORE

  7. 10. Hypoxia in arterial and venous specification during vascular development

    Author : Marcus Sohl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A developing embryo needs a constant supply of oxygen and nutrients in order to survive and grow into a functioning organism. During the earliest embryonic stages passive diffusion is enough to sustain the embryo. At later embryonic stages however, a system for delivering the necessary oxygen and nutrients to all parts of the embryo is needed. READ MORE