Search for dissertations about: "Affibody molecules"

Showing result 1 - 5 of 46 swedish dissertations containing the words Affibody molecules.

  1. 1. Affibody Molecules for PET Imaging

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Joanna Strand; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecules; Molecular imaging; PET; Radiolabelling; HER2; PDGFRβ; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. READ MORE

  2. 2. Affibody molecules for proteomic and therapeutic applications

    University dissertation from Stockholm : KTH

    Author : Caroline Grönwall; KTH.; [2008]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; protein engineering; phage display; amyloid beta peptide; transferrin; CD25; IL-2 receptor; proteomics; TECHNOLOGY Bioengineering; TEKNIKVETENSKAP Bioteknik;

    Abstract : This thesis describes generation and characterization of Affibody molecules with future applications in proteomics research, protein structure determinations, therapeutic treatment of disease and medical imaging for in vivo diagnostics. Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein A-derived Z domain scaffold. READ MORE

  3. 3. Cellular Studies of HER-family Specific Affibody Molecules

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lovisa Göstring; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EGFR; HER2; HER3; Affibody; internalisation; tumour targeting; MEDICINE; MEDICIN;

    Abstract : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. READ MORE

  4. 4. Generation and characterization of Affibody molecules targeting HER3

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Magdalena Malm; KTH.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Abstract : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. READ MORE

  5. 5. Tumour Targeting using Radiolabelled Affibody Molecules Influence of Labelling Chemistry

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mohamed Altai; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HER2; Affibody molecule; Radionuclide molecular maging; Targeted radionuclide therapy; Labeling chemistry;

    Abstract : Affibody molecules are promising candidates for targeted radionuclide-based imaging and therapy applications. Optimisation of targeting properties would permit the in vivo visualization of cancer-specific surface receptors with high contrast. In therapy, this may increase the ratio of radioactivity uptake between tumour and normal tissues. READ MORE