Search for dissertations about: "Affibody molecules"
Showing result 16 - 20 of 61 swedish dissertations containing the words Affibody molecules.
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16. Affibody-mediated targeting of HER-family receptors for cancer imaging and therapy
Abstract : Proteins are remarkable molecules with diverse and specialized functions playing essential roles in most biological processes. One such function is protecting us from diseases by the action of antibodies in our immune system that can recognize and mediate the destruction of invading pathogens by binding to foreign epitopes found on non-self proteins. READ MORE
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17. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting
Abstract : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. READ MORE
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18. Affibody Molecules Targeting VEGFR2 - Two Turns Off and Four Turns On
Abstract : The notion of employing proteins as drugs traces back several decades. As recombinant DNA technology emerged, it became a powerful tool for the tailoring of protein traits via genetic approaches - so-called protein engineering. READ MORE
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19. Development of Affibody molecules for radionuclide molecular imaging and therapy of cancer
Abstract : Affibody molecules are a promising class of scaffold-based targeting proteins for radionuclide-based imaging and therapy of cancer. This thesis work is based on 5 original research articles (papers I-V), which focus on optimization of molecular design of HER2-binding Affibody variants for high contrast imaging of this predictive biomarker as well as development of Affibody molecules suitable for radionuclide-based targeted therapies. READ MORE
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20. Affibody molecules targeting the epidermal growth factor receptor for tumor imaging applications
Abstract : Tumor targeting and molecular imaging of protein markers specific for or overexpressed in tumors can add useful information in deciding upon treatment and assessing the response to treatment for a cancer patient. The epidermal growth factor receptor (EGFR) is one such tumor-associated receptor, which expression is abnormal or upregulated in various cancers and associated with a poor patient prognosis. READ MORE