Search for dissertations about: "Affibody molecules"

Showing result 21 - 25 of 61 swedish dissertations containing the words Affibody molecules.

  2. 21. PNA and affinity protein tools for selective tumor targeting of radiopharmaceuticals

    Author : Hanna Tano; Amelie Eriksson Karlström; Per-Åke Nygren; Dario Neri; KTH; []
    Keywords : Cancer therapy; targeted radionuclide therapy; affinity proteins; Affibody molecules; CD38; GRPR; HER2; nanobody; peptide; PNA; RM26; pretargeting; Cancerterapi; radionuklid terapi; affinitetsproteiner; affibody molekyler; CD38; GRPR; HER2; nanobody; peptid; PNA; RM26; pretargeting; Biotechnology; Bioteknologi;

    Abstract : Targeted radiotherapy of cancer intends to selectively deliver cytotoxic radionuclides to tumor cells. Affinity proteins of various kinds are explored for this task, and depending on the affinity protein used, different challenges arise. READ MORE

  4. 22. Targeting HER2-expressing tumors with potent drug conjugates and fusion toxins based on scaffold proteins

    Author : Haozhong Ding; Torbjörn Gräslund; Stefan Ståhl; Harald Kolmar; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Targeted therapy; affibody molecules; ADAPT molecules; AffiDC; fusion toxins; HER2; Biotechnology; Bioteknologi;

    Abstract : Targeted therapy is an emerging treatment for a variety of cancers. Small- sized scaffold proteins are an alternative to conventional antibody-based targeting molecules. READ MORE

  5. 23. Platforms and strategies harnessing signaling pathways of multifactorial diseases by multispecific antibodies

    Author : Aman Mebrahtu; Johan Rockberg; Fredrik Y. Frejd; Janine Schuurman; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibodies; Bispecific antibodies; Multispecific affinity proteins; Protein engineering; Protein expression; Cancer; Immunotherapy; Autoimmunity; Systemic Lupus Erythematosus; Affibody molecules; AffiMab; Antikroppar; Bispecifika antikroppar; Multispecifika affinitets protein; Protein engineering; Protein uttryck; Cancer; Immunoterapai; Autoimmunitet; Systemic Lupus Erythematosus; Affibody molekyler; AffiMab; Biotechnology; Bioteknologi;

    Abstract : Abstract [ENG]Proteins govern a multitude of biological functions vital to sustain life. The ability to withstand diseases development and harboring a defense against foreign pathogens is attributed to the wonders of the immune system and the proteins and cells its comprised of. READ MORE

  6. 24. Fluorescence-based ligand assays for protein detection using affibody affinity proteins

    Author : Björn Renberg; Amelie Eriksson Karlström; Per-Åke Nygren; Jörg Hoheisel; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; biosensors; FRET; immobilisation; solid-phase synthesis; protein microarrays; Biochemistry; Biokemi;

    Abstract : The detection and quantification of biomolecules, and proteins in particular, are of great interest since these molecules are of fundamental importance to our well-being. Body fluids, as for instance human blood, are well suited for sampling of protein levels. READ MORE

  7. 25. Affibody-Based Molecular Imaging and Targeted Therapy of HER3-Expressing Cancer

    Author : Sara Sophie Rinne; Anna Orlova; Vladimir Tolmachev; Mohamed Altai; Anzhelika Vorobyeva; Melpomeni Fani; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular Imaging; PET; SPECT; Cancer; Affibody; HER3; Targeted Therapy;

    Abstract : The human epidermal growth factor receptor type 3 (HER3) is overexpressed in different types of cancer and is a known contributor to disease progression and resistance to cancer therapy. This thesis is based on five original articles, which aimed to improve the diagnostic and therapeutic potential of affibody-based agents for management of HER3-expressing cancers. READ MORE