Search for dissertations about: "African trypanosomiasis"

Showing result 1 - 5 of 14 swedish dissertations containing the words African trypanosomiasis.

  1. 1. Novel Treatment of African Trypanosomiasis

    University dissertation from Stockholm : Karolinska Institutet, Dept of Microbiology, Tumor and Cell Biology

    Author : Suman Kumar Vodnala; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. READ MORE

  2. 2. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

    University dissertation from Umeå : Medicinsk kemi och biofysik

    Author : Artur Fijolek; Umeå universitet.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. READ MORE

  3. 3. Immunopathology and signalling molecules involved during experimental African trypanosomiasis

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine at Huddinge University Hospital

    Author : Ragaa Abdelkhalig Eltayeb; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; African Trypanosomiasis; Cytokines; Chemokines; Co-stimulatory molecules; Immunopathogenesis; T.b. brucei;

    Abstract : In humans, African trypanosomiasis occurs in two forms; the chronic West African form is caused by T.b. gambiense and the acute or subacute East African form is caused by T.b. READ MORE

  4. 4. Parasite signalling and host responses in experimental and human African trypanosomiasis

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine

    Author : Maha Hamadien; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TLTF; anti-TLTF antibodies; IFN-gamma; Human African trypanosomiasis; T b. brucei; ;

    Abstract : African trypanosomiasis or sleeping sickness is a disease of tropical Africa caused by the unicellular-flagellated protozoan parasite, Trypanosoma brucei (T b.), which is transmitted by its insect vector, the tsetse fly. In humans, there are two forms of the disease: a chronic form in West and Central Africa, caused by T. b. READ MORE

  5. 5. Drug Analysis Bioanalytical Method Development and Validation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mikaela Malm; Uppsala universitet.; [2008]
    Keywords : Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries.Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. READ MORE