Search for dissertations about: "African trypanosomiasis"

Showing result 1 - 5 of 15 swedish dissertations containing the words African trypanosomiasis.

2. 1. Novel treatment of African trypanosomiasis

   Author : Suman Kumar Vodnala; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. READ MORE

4. 2. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

   Author : Artur Fijolek; Lars Thelander; Arne Holmgren; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; Biochemistry; Biokemi;

   Abstract : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. READ MORE

5. 3. Immunopathology and signalling molecules involved during experimental African trypanosomiasis

   Author : Ragaa Abdelkhalig Eltayeb; Karolinska Institutet; Karolinska Institutet; []
   Keywords : African Trypanosomiasis; Cytokines; Chemokines; Co-stimulatory molecules; Immunopathogenesis; T.b. brucei;

   Abstract : In humans, African trypanosomiasis occurs in two forms; the chronic West African form is caused by T.b. gambiense and the acute or subacute East African form is caused by T.b. READ MORE

6. 4. Oral eflornithine treatment of late-stage human African trypanosomiasis

   Author : Mikael Boberg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sleeping Sickness; Neglected Tropical Diseases; Enantiomers; Nonlinear Mixed Effects Modeling; Pharmacokinetics; Pharmacodynamics;

   Abstract : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. READ MORE

7. 5. Parasite signalling and host responses in experimental and human African trypanosomiasis

   Author : Maha Hamadien; Karolinska Institutet; Karolinska Institutet; []
   Keywords : TLTF; anti-TLTF antibodies; IFN-gamma; Human African trypanosomiasis; T b. brucei; ;

   Abstract : African trypanosomiasis or sleeping sickness is a disease of tropical Africa caused by the unicellular-flagellated protozoan parasite, Trypanosoma brucei (T b.), which is transmitted by its insect vector, the tsetse fly. In humans, there are two forms of the disease: a chronic form in West and Central Africa, caused by T. b. READ MORE