Search for dissertations about: "Agonist"

Showing result 16 - 20 of 434 swedish dissertations containing the word Agonist.

  2. 16. Strategies to improve outcome after islet transplantation using the GLP-1 receptor agonist, extendin-4

    Author : Amit Sharma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Transplantation of pancreatic islets into the liver via the portal vein has emerged as a treatment option for patients with type I diabetes mellitus. However, loss of functional beta cell mass during isolation and following implantation is a major obstacle in obtaining good long-term results. READ MORE

  4. 17. Synthesis of Molecular Probes for Exploring the Human Consciousness, 5-HT7 Ligands and Salvinorins

    Author : Pär Holmberg; Anders Karlén; Adolf Gogoll; Anette Johansson; Christer Sahlberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; serotonin system; opioid system; selective 5-HT7 agonist; 3-aminchromans; salvinorin A; selective kappa opioid receptor; mental disorders; consciousness; regioselective oxidation; enzymatic kinetic resolution; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : In this study, we have addressed the serotonergic and the opioid system within the CNS. Both systems are of outmost importance in the etiology of disease states, especially mental disorders. READ MORE

  5. 18. Experimental Injury to the Visual System : Molecular Studies of the Retina

    Author : Ulrika Lönngren; Finn Hallböök; Fredrik Ghosh; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retina; injury; ischemia; gene expression; brimonidine; alpha-2-adrenergic agonist; neuroprotection; growth factors; apoptosis; Müller cells; Neuroscience; Neurovetenskap;

    Abstract : Retinal ganglion cells play a crucial role in the relay of visual signals from the eye to the brain. This cell type is affected and eventually lost in the eye disease glaucoma, resulting in progressive and irreversible loss of vision. READ MORE

  6. 19. Opioids and regulation of breathing

    Author : Åsa Österlund Modalen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Sameridine; partial - opioid agonist; local anesthetic; morphine; ventilation; respiratory depression; hypercarbia; hypoxia; frakefamide; peripheral -opioid agonist;

    Abstract : A most important challenge even in modern medicine is effective treatment of pain. Respiratory depression is the most feared side effect of analgesic treatment in the clinical situation. READ MORE

  7. 20. Is it Just the Hormones? : Sex Steroids, Chronic Stress and Violence in Premenstrual Dysphoric Disorder

    Author : Birgitta Segebladh; Inger Sundström-Poromaa; Marie Bixo; Kristina Gemzell-Danielsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; premenstrual dysphoric disorder; combined oral contraceptive; GnRH agonist; add-back; estradiol; progesterone; chronic stress; intimate partner violence; depression; anxiety; allopregnanolone; Obstetrics and gynaecology; Obstetrik och gynekologi; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Premenstrual depressive symptoms and mood swings affect 3-8% of women in fertile age. The female hormones are believed to be the cause. Progesterone is well studied, but estrogen is not, and either are other causes such as intimate partner violence and chronic stress. READ MORE