Search for dissertations about: "AhR-mediated activity"

Showing result 1 - 5 of 7 swedish dissertations containing the words AhR-mediated activity.

  2. 1. Characterization of PAC-contaminated soil with the focus on availability, leachability and biological activities

    Author : Monika M. Lam; Magnus Engwall; Maria Larsson; Patrik Andersson; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Polycyclic aromatic compounds; Availability; Mobility; Soil; Risk assessment; AhR-mediated activity; ER-mediated activity;

    Abstract : Current risk assessments of polycyclic aromatic compounds (PACs)-contaminated soil are often based on the 16 priority PAHs and do not consider availability of PACs in soil sufficiently. This may lead to uncertainties of the assessment, since important contaminants can be overlooked and only a small fraction of contaminants is available for the uptake for organisms. READ MORE

  4. 2. Chemical and bioanalytical characterisation of PAH-contaminated soils : identification, availability and mixture toxicity of AhR agonists

    Author : Maria Larsson; Magnus Engwall; Jessika Hagberg; Peter Haglund; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Polycyclic aromatic compounds; Soil; Risk assessment; Mixture studies; AhR-mediated activity; REPs; GC MS; H4IIE-luc bioassay; Chemistry; Kemi;

    Abstract : Contaminated soils are a worldwide problem. Polycyclic aromatic hydrocarbons (PAHs) are common contaminants in soil at former industrial areas, especially at old gasworks sites, gas stations and former wood impregnation facilities. READ MORE

  5. 3. Molecular mechanisms of AhR mediated endocrine disruption of estrogen and retinoic acid signalling pathways

    Author : David Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is considered to be one of the most toxic compounds known to man. READ MORE

  6. 4. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

    Author : Camilla Svensson; Lars Wärngård; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; 2; 3; 7; 8-Tetrachlorodibenzo-p-dioxin; TCDD; adseverin; aryl hydrocarbon receptor; immunotoxicity; thymus; cytoskeleton; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

    Abstract : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. READ MORE

  7. 5. Health risk assessment of dioxin-like compounds in complex samples

    Author : Mattias U L Öberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : There are several scientific as well as political and economic reasons why the risk assessment of dioxins in complex samples needs to be further refined. Today, there seems to be no margin of safety between doses that cause suspected effects and exposure. Therefore, uncertainties and gaps in the knowledge have to be minimized. READ MORE