Search for dissertations about: "Aire"

Showing result 1 - 5 of 14 swedish dissertations containing the word Aire.

2. 1. Thymic studies. Investigations into the effects of childhood thymectomy, and characterization of thymic B cells and Hassall's corpuscles

   Author : Christina Lundqvist; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thymus; thymectomy; TCR; B cells; APC; Hassall s corpuscles; AIRE;

   Abstract : This thesis focuses on the human thymus, a primary lymphoid organ responsible for the maturation of T cells. Progenitors arrive from the bone marrow and start to randomly assemble their T cell receptor (TCR) followed by a thorough selection process in which the TCR is tested for functionality and autoreactivity. READ MORE

4. 2. Organ-specific autoantibodies in Addison's disease and autoimmune polyendocrine syndrome type I

   Author : Annika Söderbergh; Uppsala universitet; []
   Keywords : Medical sciences; Addison s disease; APS I; Down syndrome; AIRE; autoantibodies; autoantigens; autoimmunity; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Abstract : Assessment of autoantibodies is a valuable tool in the diagnostic procedure of autoimmune diseases. The aim of this study was to investigate the prevalence of different autoantibodies and their associations with disease manifestations in patients with Addison's disease and autoimmune polyendocrine syndrome type I (APS I). READ MORE

5. 3. Characteristics and functions of thymic exosomes in human and mouse

   Author : Gabriel Skogberg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exosome; thymus; tissue-restricted antigen; Aire; Down syndrome;

   Abstract : Thymocytes develop in the thymus to become a functional pool of T-cells in the periphery. To achieve this, the thymocytes go through several steps of maturation and selection within the thymus. READ MORE

6. 4. Studies on peripheral tolerance in Aire-deficient mice

   Author : Evelina Lindmark; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Autoimmune diseases such as diabetes mellitus and multiple sclerosis are increasing today, but the mechanism behind these diseases remains largely unknown. Autoimmunity arise when the immune system of an individual start to attack its own organs and tissues. READ MORE

7. 5. Autoimmune Regulator Deficient Mice, an Animal Model of Autoimmune Polyendocrine Syndrome Type I

   Author : Signe Hässler; Ola Winqvist; Olle Kämpe; Bertrand Huard; Uppsala universitet; []
   Keywords : Molecular medicine; autoimmune regulator; autoimmune polyendocrine syndrome type I; peripheral tolerance; antigen presenting cells; autoimmunity; danger signal; knockout mice; Molekylärmedicin;

   Abstract : Autoimmune diseases develop when the immune system fails to distinguish self from non-self or when the immune system is hypersensitive to endogenous or exogenous danger signals, or when a tissue erroneously sends a danger signal to the immune system. The education of the immune system to distinguish self from non-self is mainly carried out in the thymus and gives rise to central tolerance, whereas the ability to sense a danger or a healthy tissue constitutes peripheral tolerance. READ MORE