Search for dissertations about: "Airway provocations"

Showing result 1 - 5 of 6 swedish dissertations containing the words Airway provocations.

  1. 1. The asthmatic airway response – effects on physiology and biomarkers

    Author : Henning Stenberg; allergologi och palliativ medicin Lungmedicin; []
    Keywords : Asthma; Exhaled breath temperature; Exercise; Allergen challenge; Small airways; Airway provocations; Spirometry; Impulse oscillometry; Inert gas washout; Body plethysmography; Club cell protein CC16 ;

    Abstract : Asthma is a common airway inflammatory disease, associated with a variable degree of airway obstruction. It is a heterogeneous condition with large variations in severity and clinical presentation. Moreover, disease activity can vary from time to time. Taken together, these factors make the diagnosis, monitoring and treatment of asthma challenging. READ MORE

  2. 2. Effects of Inflammatory Mediators on Pulmonary Airways

    Author : Ofir Bachar; Klinisk och experimentell allergiforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electric ?eld stimulation; bradykinin; airway; tumor necrosis factor a; Respiratory system; nitric oxide; Andningsorganen; Toll-like receptor; prostaglandin E2; neurotrophin; allergy;

    Abstract : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. READ MORE

  3. 3. Bronchoprovocation studies to define mechanisms in asthma and airway inflammation

    Author : Nikolaos Lazarinis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Bronchial provocations with a variety of stimuli have been widely used over the past 70 years in both asthma research as well as in daily clinical praxis in order to aid the physician to establish the asthma diagnosis. In research, the bronchoprovocation model represents an excellent tool to better understand asthma pathophysiology, and to assess the effects of different interventions and new investigational therapies. READ MORE

  4. 4. Studies of exercise-induced bronchoconstriction to define protective mechanisms in asthma

    Author : Johan Bood; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Exercise-induced bronchoconstriction (EIB) occurs in the majority of asthmatics following vigorous exercise. EIB is caused by a loss of water from the airways creating a hyperosmolar environment in the tissue that in turn triggers the release of bronchoconstrictive mediators. READ MORE

  5. 5. The contribution of eosinophils and mediators in allergic inflammation

    Author : Annika Roquet; Karolinska Institutet; Karolinska Institutet; []
    Keywords : allergic inflammation; eosinophils; bronchial hyperresponsiveness; histamine; leukotrienes; antihistamine; leukotriene-antagonist; low-dose challenge;

    Abstract : The aim of the present work was to investigate the development of allergic inflammation. For this purpose human experimental challenge models in skin, nose and bronchi were used as well as pharmacological interventions. A variety of inflammatory cells and mediators have been suggested as important in the pathogenesis of allergic inflammation. READ MORE