Search for dissertations about: "Akt kinase"
Showing result 1 - 5 of 123 swedish dissertations containing the words Akt kinase.
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1. Integrin Signaling in Cell Adhesion and Mechanotransduction : Regulation of PI3K, AKT, and ROS
Abstract : Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. READ MORE
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2. Hormone-Sensitive Lipase and Protein Kinase B; Molecular characterization in testis, adipose tissue and pancreatic beta cells
Abstract : Hormone-sensitive lipase (HSL) and protein kinase B (PKB) are enzymes that in different ways are associated with lipid metabolism. While HSL is the well-known lipolytic enzyme responsible for hydrolysis of stored triacylglycerols in adipose tissue, PKB is a recently identified serine/threonine protein kinase, ubiquitously expressed and involved in signal transduction pathways induced by insulin and growth factors. READ MORE
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3. Colorectal cancer and radiation response : The role of EGFR, AKT and cancer stem cell markers
Abstract : The primary treatment for colorectal cancer is surgery. Radiotherapy and chemotherapy, sometimes combined, are also frequently used to diminish recurrence risk. In response to radiation exposure, several cellular signaling cascades are activated to repair DNA breaks, prevent apoptosis and to keep the cells proliferating. READ MORE
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4. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation
Abstract : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. READ MORE
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5. Oncogenic ALK signaling in neuroblastoma
Abstract : Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. READ MORE