Search for dissertations about: "Akt kinase"

Showing result 16 - 20 of 123 swedish dissertations containing the words Akt kinase.

  2. 16. Integrin α2 and Akt in early hematopoiesis

    Author : Wan Man Wong; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Hematopoiesis is a tightly regulated process in which hematopoietic stem cells reside at the apex of the hierarchy, and produce all kinds of mature blood cells by differentiation to replenish the cell loss in homeostasis and acute injury. In past few decades, much effort has been made to purify hematopoietic stem cells (HSCs) and lineagecommitted progenitor cells both in mouse and human, enabling further characterization of these cell populations not only in normal hematopoiesis, but also in various hematological malignancies. READ MORE

  4. 17. The Akt/mTOR Pathway and Estrogen Receptor Phosphorylations : a crosstalk with potential to predict tamoxifen resistance in breast cancer

    Author : Josefine Bostner; Olle Stål; Cecilia Bivik; Malin Sund; Linköpings universitet; []
    Keywords : ;

    Abstract : Estrogen receptor α content is the primary breast cancer biomarker distinguishing the patients responsive from the non-responsive to endocrine treatments. Tamoxifen is an estrogen competitor with large potential to treat breast cancer patients and prolongs time to recurrence. READ MORE

  5. 18. Exercise effects on the mitogen-activated protein (MAP) kinase cascade in skeletal muscle

    Author : Ulrika Widegren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skeletal muscle; MAP kinase; contraction; acute exercise; Akt kinase; exercise intensity; signal transduction; fiber-type;

    Abstract : Exercise-induced adaptations in skeletal muscle are regulated by numerous signaling mechanisms. However, little is known about the molecular signaling mechanisms linking muscle contraction or other exercise-associated stimuli to intracellular responses in skeletal muscle. READ MORE

  6. 19. Novel Roles of the Ack1 Kinase in Epithelial Biology

    Author : Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. READ MORE

  7. 20. Mechanisms of survival and maintenance of Hematopoietic Stem Cells and Multipotent Progenitor Cells

    Author : Richard Karlsson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; hypoxia.; forkhead; Akt PKB; Bcl-2; apoptosis; Flt3; FL; c-kit; KL; cytokines; Hematopoiesis; progenitor;

    Abstract : Hematopoietic stem cells and progenitor cells are maintained in the bone marrow microenvironment, where factors including soluble and membrane-bound cytokines influence the processes of self-renewal, proliferation and differentiation. Two nonreduntant cytokines with effects on hematopoiesis, Kit Ligand (KL) and Flt3 Ligand (FL), signal via related tyrosine kinase receptors, c-kit and Flt3. READ MORE