Search for dissertations about: "Akt"
Showing result 6 - 10 of 223 swedish dissertations containing the word Akt.
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6. From 1p3 to PI3K - Studies of neuroblastoma
Abstract : Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is still fatal for patients with aggressive NB and side-effects of treatment are severe. READ MORE
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7. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation
Abstract : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. READ MORE
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8. Non-canonical TGFb signaling pathways in prostate cancer
Abstract : Prostate cancer is the second leading cause of cancer-related death in men in the Western world. Deregulation of transforming growth factor β (TGFβ) signaling pathway is frequently detected in prostate cancer and contributes to tumor growth, migration, and invasion. READ MORE
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9. Oncogenic ALK signaling in neuroblastoma
Abstract : Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. READ MORE
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10. Protein expression and modifications in denervated atrophic and hypertrophic skeletal muscle
Abstract : Skeletal muscle comprises about 45% of the total body weight. It is the largest tissue in the body, vital for maintaining posture, produce locomotion, breathing but also functions as a large reservoir of proteins. READ MORE