Search for dissertations about: "Aldehyde dehydrogenase"

Showing result 1 - 5 of 20 swedish dissertations containing the words Aldehyde dehydrogenase.

2. 1. Exploring the heterogeneity of the hematopoietic stem and progenitor cell pool in cord blood

   Author : Sofia Frändberg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cord blood; Cord blood bank; Cord clamping; Hematopoietic stem cell transplantation; Hematopoietic stem and progenitor cells; CD34; Side Population; Aldehyde dehydrogenase; Apoptosis; CDCP1;

   Abstract : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for a wide range of malignant and hereditary disorders. It is yet the only clinically established stem cell treatment. READ MORE

4. 2. Aldehyde toxicity in human oral epithelium

   Author : Jan Anders Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Oral epithelium; cell cultures; toxicity; transformation; aldehydes; thiols; ADH3;

   Abstract : Human oral epithelium is an established target for aldehyde toxicity, including from usage of tobacco, intake of foods and fluids, leaching of dental materials, and from mouth inhalation of aldehydes in the work environment. Following establishment of culture/exposure protocols for oral cell cultures, toxicity mechanisms and risk of malignant transformation from aldehyde exposure was investigated, including the metabolic defense offered by alcohol dehydrogenase 3 (ADH3) against formaldehyde toxicity. READ MORE

5. 3. Function, expression and polymorphism of human alcohol dehydrogenase 3/glutathionedependent formaldehyde dehydrogenase

   Author : Jesper Hedberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Alcohol dehydrogenase 3 (ADH3), identical to glutathione-dependent formaldehyde dehydrogenase, plays a vital role in the defense against formaldehyde through the activity for the spontaneously formed adduct between formaldehyde and glutathione, Shydroxymethylglutathione (HMGSH). ADH3 may also participate in the metabolism of Snitrosylated glutathione, GSNO. READ MORE

6. 4. Oxidation of 1,2-Diols Using Alcohol Dehydrogenases : From Kinetic Characterization to Directed Evolution

   Author : Cecilia Blikstad; Mikael Widersten; Stefan Lutz; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; enzyme kinetics; alcohol dehydrogenase; directed evolution; enzyme engineering; diol; α-hydroxy aldehyde; Biokemi; Biochemistry;

   Abstract : The use of enzymes as catalysts for chemical transformations has emerged as a “greener” alternative to traditional organic synthesis. An issue to solve though, is that enzymes are designed by nature to catalyze reactions in a living cell and therefore, in many cases, do not meet the requirements of a suitable biocatalyst. READ MORE

7. 5. Structural and mechanistic aspects of alcohol dehydrogenase function

   Author : Stefan Svensson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Vertebrates possess a complex alcohol dehydrogenase (ADH) system composed of multiple molecular forms, which are currently classified into seven classes according to their structural properties. ADHs are dimeric zinc metalloenzymes that catalyze the reversible oxidation of alcohols to aldehydes/ketones using NAD+/NADH as electron acceptor and donor, respectively. READ MORE