Search for dissertations about: "Alexander Pietras"
Found 2 swedish dissertations containing the words Alexander Pietras.
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1. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization
Abstract : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. READ MORE
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2. Micro-environmental control of tumor differentiation and invasiveness
Abstract : The transforming growth factor β (TGFβ) family participates in embryonic development and adult tissue homeostasis. In early stages of tumorigenesis, TGFβ promotes cell cycle arrest and apoptosis; however, in advanced malignancies, TGFβ promotes tumor cell migration and metastasis via the induction of epithelial-tomesenchymal transition (EMT). READ MORE