Search for dissertations about: "Alexei Terman"
Found 3 swedish dissertations containing the words Alexei Terman.
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1. Mechanisms of lipofuscin/ceroid accumulation and its impact on the function of the lysosomal system
Abstract : The accumulation of lipofuscin - an electron-dense, autofluorescent, polymeric, intralysosomal substance - is a recognized hallmark of aging postmitotic cells. Ceroid- a substance very close, or perhaps even identical, to lipofuscin - is a characteristic of various pathological processes, such as lysosomal storage diseases, malnutrition, atherosclerosis, oxidative stress, ionizing radiation, etc. READ MORE
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2. Ageing-associated changes of lysosomal compartment : implications on cellular functions
Abstract : The lysosomal compartment is a major site for intracellular degradation. Lysosomal degradation of the cell’s own constituents, so-called autophagy, not only provides a cell with nutrients, but also removes damaged and potentially dangerous endogenous structures, thus securing intracellular homeostasis. READ MORE
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3. Lysosomal Involvement in the Pathogenesis of Alzheimer's Disease
Abstract : Alzheimer’s disease (AD), the major cause of senile dementia, is associated with progressive formation of neurofibrillary tangles and extraneuronal plaques composed of amyloid beta peptide (Aβ). Aβ has been also found within Alzheimer neurons in association with the lysosomal system, an acidic vacuolar compartment possessing numerous hydrolytic enzymes. READ MORE
