Search for dissertations about: "Alexey Kozlenkov"
Found 1 swedish dissertation containing the words Alexey Kozlenkov.
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1. Structural / functional studies on human alkaline phosphatases
Abstract : The recent elucidation of the three-dimensional structure of human placental alkaline phosphatase (PLAP) has enabled me to perform structural studies aimed at characterizing the properties of human PLAP and tissue-nonspecific AP (TNAP) as paradigms for mammalian APs in general, using site-directed mutagenesis, protein expression, kinetic analysis and computer modeling. In Paper I, we found that a single critical E429G substitution explains the difference in stability and kinetics between the common allelic variants of PLAP and the D allozyme. READ MORE