Search for dissertations about: "Allele sharing"
Showing result 6 - 10 of 15 swedish dissertations containing the words Allele sharing.
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6. Topics in Human Gene Mapping
Abstract : This thesis is interdisciplinary between Mathematical Statistics, Genetics, and Medicine. It mainly consists of topics in mathematical modelling of the correlation of inheritance of genes and disease in a family, a method called linkage analysis. It is organized as follows. READ MORE
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7. Evolution of Flowering Time in the Tetraploid Capsella bursa-pastoris (Brassicaceae)
Abstract : Although polyploidy is believed to be a major source of evolutionary novelty, few studies have examined the genetic basis of phenotypic variation in wild polyploids. In this thesis I have studied the genetic basis of flowering time variation in the wild tetraploid crucifer Capsella bursa-pastoris, as well as the evolutionary history of this species. READ MORE
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8. Linkage and association analysis in multiple sclerosis
Abstract : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which is characterized by relapsing or progressive demyelinating plaques in the brain and spinal cord. It is well established that complex genetic factors influence susceptibility to MS. READ MORE
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9. Candidate gene analyses and genome-wide screens in multiple sclerosis
Abstract : Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. READ MORE
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10. T cell antigen receptor usage, phenotype and cytokine production in human diseases
Abstract : T lymphocytes are of critical importance for initiating and controlling immune responses, as the T cell receptor (TCR) for antigen allows a highly specific antigen recognition. Determination of TCR usage and characterization of T cell subsets in different diseases helps us understand the underlying immunopathogenic mechanisms, and may also lead to the development of new therapeutic approaches. READ MORE