Search for dissertations about: "Allopregnanolone"

Showing result 6 - 10 of 20 swedish dissertations containing the word Allopregnanolone.

  2. 6. GABA-steroid effects in healthy subjects and women with polycystic ovary syndrome

    Author : Helena Hedström; Torbjörn Bäckström; Marie Bixo; Ian Milsom; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; isoallopregnanolone; gonadotropins; GABA-A receptor; women; polycystic ovary syndrome; saccade; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background: The progesterone metabolite allopregnanolone is involved in several clinical conditions in women, e.g. premenstrual dysphoric disorder. It is a very potent GABA-steroid with GABA-A receptor effects similar to other GABA-agonists, e. READ MORE

  4. 7. Progesterone metabolites : learning, tolerance, antagonism & metabolism

    Author : Charlotte Öfverman; Inga-Maj Johansson; Torbjörn Bäckström; Esa Korpi; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allopregnanolone; isoallopregnanolone; THDOC; learning; tolerance; antagonism; inhibition; patch clamp; Morris water maze; metabolism; epimerization; Obstetrics and gynaecology; Obstetrik och gynekologi; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Progesterone metabolites as allopregnanolone, isoallopregnanolone and tetrahydrodeoxy-corticosterone (THDOC) are increased in the luteal phase of the menstrual cycle, throughout pregnancy and during stress. Allopregnanolone and THDOC are neurosteroids with 3α-hydroxy, 5α-configurations and positive modulating effect on the GABAA receptor. READ MORE

  5. 8. Neuroactive steroids and rat CNS

    Author : Vita Birzniece; Bo Söderpalm; Umeå universitet; []
    Keywords : Estradiol; progesterone; HRT; allopregnanolone; UC1011; serotonin receptor; GABAA receptor; mRNA; Morris water maze; silent second; tolerance; Clinical Neurophysiology; klinisk neurofysiologi;

    Abstract : Several studies suggest profound effects on mood and cognition by neuroactive steroids. Estrogen alone or in combination with antidepressant drugs affecting the serotonin system has been used to treat mood disorders. On the other hand, progesterone is related to negative effects on mood and memory. READ MORE

  6. 9. Premenstrual dysphoric disorder in relation to neuroactive steroids and alcohol

    Author : Sigrid Nyberg; Britth-Marie Landgren; Umeå universitet; []
    Keywords : premenstrual dysphoric disorder; GnRH-agonist; progesterone; allopregnanolone; alcohol; saccadic eye velocity; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Introduction: Premenstrual Dysphoric Disorder (PMDD) is a condition that affects about 2-6% of women of reproductive age. The relation to ovarian steroids is apparent as symptoms are absent during anovulatory cycles. READ MORE

  7. 10. Physiological Stress Reactivity in Late Pregnancy

    Author : Charlotte Hellgren; Inger Sundström-Poromaa; Helena Åkerud; Mats Hammar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acoustic startle response; allopregnanolone; antenatal; anxiety; cold pressor test; cortisol; cortisol awakening response; depression; electrodermal; estradiol; hypothalamic-pituitary-adrenal axis; postpartum; pregnancy; progesterone; skin conductance; stress; sympathetic nervous system; Medical Science; Medicinsk vetenskap;

    Abstract : During pregnancy, the basal activity is increased in both of our major stress response systems: the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. At the same time, the reactivity towards stressors is reduced. These alterations sustain maternal and fetal homeostasis, and are involved in the regulation of gestational length. READ MORE