Search for dissertations about: "Alpha 1 microglobulin"
Showing result 1 - 5 of 15 swedish dissertations containing the words Alpha 1 microglobulin.
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1. Alpha-1-microglobulin: Innate defence against pathological oxidation
Abstract : Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. READ MORE
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2. Structure and distribution of alpha-1-microglobulin proteins
Abstract : This thesis describes studies of the structure and tissue distribution of alpha-1-microglobulin (a1-m), a member of the lipocalin protein superfamily with immunosuppressive properies. It was shown that a1-m appears in human plasma in five major forms. READ MORE
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3. Alpha-1-microglobulin, heme-binding protein, reductase and antioxidant
Abstract : This thesis describes structural and functional studies of alpha-1-microglobulin (a1m), a 26 kDa plasma and tissue protein that is evolutionarily well-conserved and belongs to the lipocalin superfamily. The lipocalins are polypeptides of 160-190-amino acids that are folded into an 8-stranded beta-barrel forming a pocket with a hydrophobic interior. READ MORE
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4. Urinary Clara cell protein and alpha 1-microglobulin – biomarkers of changes in kidney and airway function
Abstract : Validated biomarkers are useful tools for screening large populations. The benefit of screening may be improved risk assessment or early indications of adverse effects before detection or onset of symptoms. READ MORE
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5. Therapeutic opportunities of alpha-1-microglobulin A study in placenta, blood, skin and eye
Abstract : This thesis describes functional studies of the human protein alpha-1-microglobulin (A1M), with the aim of exploring its usefulness as a therapeutic agent in diseases where oxidative stress is a prominent feature. A1M is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding antioxidative functions. READ MORE