Search for dissertations about: "Alzheimer’s disease"

Showing result 16 - 20 of 579 swedish dissertations containing the words Alzheimer’s disease.

  2. 16. Enhancing the therapeutic effect of biological drugs with protein engineering : Focusing on pre-clinical Alzheimer’s disease therapy

    Author : Fadi Rofo; Greta Hultqvist; Stina Syvänen; Sara Mangsbo; Joy Zuchero; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloid-beta; blood-brain barrier; transferrin receptor; protein-drugs; multivalent-bispecific antibodies;

    Abstract : Aggregation of the amyloid-β peptide (Aβ) is one of the main pathological hallmarks in Alzheimer’s disease (AD). The soluble Aβ aggregates (oligomers and protofibrils) have shown to be the most harmful species. Hence, targeting these aggregates can be of therapeutic potential. READ MORE

  4. 17. Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia

    Author : Mattias Haglund; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; pathological anatomy; General pathology; Vascular dementia; Alzheimer s disease; Cerebral infarction; Locus ceruleus; White matter; Microvasculature; Cerebrovascular disease; patologisk anatomi; Ischemia; Cerebral amyloid angiopathy;

    Abstract : Dementia is a state of permanent loss of cognitive function, most commonly affecting the elderly. With a rapidly growing aged population, the spectrum of disorders that lead to dementia is exerting an ever-increasing toll on patients, families and society alike. The most common dementing disorders are Alzheimer's disease and vascular dementia. READ MORE

  5. 18. Detection of Differentially Expressed Genes in Alzheimer's Disease : Regulator of G-protein Signalling 4: A Novel Mediator of APP Processing

    Author : Lina Emilsson; Elena Jazin; Karoly Mirnics; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; RGS4; ITPKB; RAB3A; APP processinig; Biology; Biologi;

    Abstract : Alzheimer’s disease is a neurodegenerative disease characterised by progressive memory deterioration and cognitive impairment. Pathological hallmarks are extracellular senile plaques, neurofibrillary tangles and neuron loss. Senile plaques are produced through altered processing of the membrane-bound protein APP. READ MORE

  6. 19. Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease

    Author : Joakim Hertze; Klinisk minnesforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; mild cognitive impairment; white matter lesions; brain reserve; blood-brain barrier; angiogenesis; neuroinflammation; neurogranin; YKL-40; VEGF; IGF; ICAM-1; VCAM-1;

    Abstract : Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. READ MORE

  7. 20. Biomarkers for Alzheimer's disease and the APOE polymorphism

    Author : Ronald Lautner; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Biomarkers; APOE; Cerebrospinal fluid; β-amyloid;

    Abstract : Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) reflecting amyloid plaque pathology, phosphorylated tau (P-tau) reflecting neurofibrillary tangle pathology and total tau (T-tau) reflecting general neurodegeneration. In addition, blood-based biomarkers for AD are in the pipeline with recent studies showing promising diagnostic potential. READ MORE