Search for dissertations about: "Alzheimer’s disease"

Showing result 21 - 25 of 579 swedish dissertations containing the words Alzheimer’s disease.

  2. 21. Polysaccharides in Alzheimer's disease and inflammation-associated amyloidosis

    Author : Birgitta Lindahl; Uppsala universitet; []
    Keywords : Medical sciences; Alzheimer s disease; amyloid; heparan sulfate; keratan sulfate; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Amyloidosis is a term for diseases that share a common feature: the extracellular deposition of amyloid fibrils, that consist of a single protein prone to aggregate. Polysaccharides (glycos-aminoglycans), especially heparan sulfate, are significant components of all types of amyloid deposits. READ MORE

  4. 22. Preclinical PET imaging and therapy of Alzheimer's disease

    Author : Silvio R. Meier; Stina Syvänen; Dag Sehlin; Greta Hultqvist; Matthias Brendel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; positron emission tomography PET ; bispecific antibody; BACE-1; TREM2; GFAP; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

    Abstract : The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles, containing tau protein. Because of misfolded and aggregated proteins, activated microglia and astroglia react with a neuroinflammatory response, which may contribute to disease progression and severity. READ MORE

  5. 23. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization

    Author : Nicklas Österlund; Astrid Gräslund; Leopold L. Ilag; Mikael Oliveberg; Sheena E. Radford; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein aggregation; amyloid-β; neurodegeneration; Alzheimer’s disease; chaperones; DnaJ; biomembranes; native mass spectrometry; Biophysics; biofysik;

    Abstract : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. READ MORE

  6. 24. Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease

    Author : Erik Stomrud; Klinisk minnesforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; EEG; phosphorylated tau protein; amyloid beta protein; tau protein; cerebrospinal fluid; biomarkers; preclinical Alzheimer s disease; Alzheimer s disease; MCI; dementia; SPECT; memory; cognition; early diagnosis; control groups;

    Abstract : Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. READ MORE

  7. 25. Neuropsychiatric symptoms in early stages of Alzheimer’s disease: associations with neuropathological changes and cognitive deficits

    Author : Maurits Johansson; Helsingborg Kliniska Vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuropsychiatric symptoms; Apathy; Depression; Anxiety; Mild Behavioral Impairment; Mild cognitive impairment; Dementia; Alzheimer s disease; Psychometric testing; Cognitively healthy elderly; Amyloid; Tau; Cerebrospinal fluid CSF ; Positron emission tomography PET ; Cognition; Neurodegenerative disease;

    Abstract : .... READ MORE