Search for dissertations about: "Alzheimer drug"
Showing result 1 - 5 of 16 swedish dissertations containing the words Alzheimer drug.
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1. Mitochondria in Alzheimer disease : regulatory mechanisms and cell death
Abstract : Synaptic loss is the major correlate for cognitive decline in Alzheimer disease (AD). Processes taking place in the synapses are highly energy demanding and needs strict regulation, which makes the mitochondria and ER crucial at these sites so as to supply energy and spatially regulate intracellular calcium signaling. READ MORE
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2. Aspects on heart failure and drug treatment in geriatric patients
Abstract : Background: Patients with chronic heart failure (HF) are very common in geriatric care, but the prevalence of different types of HF and comorbidities, as well as the nature of investigations, treatment, planning and outcome in this patient group are less well known. The overall aim of this thesis was to assess central aspects of geriatric care such as strategies for drug changes and in particular, investigations and treatment strategies for geriatric patients with HF prior to and during geriatric care. READ MORE
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3. Alzheimer disease : a super-resolved picture of the amyloid β-peptide producing machinery
Abstract : Alzheimer disease (AD) is the most common neurodegenerative disease, influencing 40 million patients in the world. Pathologically, AD is hallmarked by intracellular tau tangles and extracellular Amyloid-β peptide (Aβ) plaques. Aβ is generated from the amyloid precursor protein (APP) and its C-terminal fragment (APP-CTF). READ MORE
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4. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer disease
Abstract : An important neurophathological hallmark of Alzheimer disease (AD) is the progressive formation of neurofibrillary tangles composed of aberrant hyperphosphorylated tau aggregates. Evidence from human postmortem AD brains and in vitro and in vivo rapamycin-treated drug models implicated an abnormal accumulation of the mammalian target of rapamycin (mTor) in AD brains. READ MORE
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5. Functional brain activity in Alzheimer patients as studied by multi-tracer positron emission tomography : effects of treatment with cholinesterase inhibitors
Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disease accompanied by cognitive impairment and disturbances in several neurotransmitter systems, especially the cholinergic system. Studies have correlated the cognitive impairment observed in AD patients with a deficit in central cholinergic neurotransmission. READ MORE
