Search for dissertations about: "Alzheimer s disease detection"

Showing result 1 - 5 of 10 swedish dissertations containing the words Alzheimer s disease detection.

  1. 1. Clusterin in brain and cerebrospinal fluidin Alzheimer s disease

    Author : Anna-Maria Nilselid; Göteborgs universitet; []
    Keywords : Alzheimer s disease; clusterin; apolipoprotein J; SP-40; brain tissue; cerebrospinal fluid; glycosylation; biomarker; enzyme-linked immunosorbent assay;

    Abstract : The apolipoprotein clusterin is suggested to be involved in the pathogenesis of Alzheimer¡¦s disease (AD). At the start of these studies, results had indicated that clusterin was elevated in AD brain, compared with controls. READ MORE

  2. 2. Development of proteomic methods for studying cerebrospinal fluid proteins involved in Alzheimer´s disease

    Author : Maja Puchades; Göteborgs universitet; []
    Keywords : Alzheimer s disease; cerebrospinal fluid; proteomics; mass spectrometry; biomarkers; synaptic proteins; liquid phase IEF; biomarkers;

    Abstract : Alzheimer's disease (AD) is the most common cause of dementia in western countries. The main neuropathological findings in the AD brain are senile plaques, neurofibrillary tangles and degeneration of neurons and synapses. READ MORE

  3. 3. Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders

    Author : Sara Folkesson Hansson; Göteborgs universitet; []
    Keywords : Alzheimer?s disease; frontotemporal dementia; cerebrospinal fluid; neurodegeneration; proteomics; mass spectrometry; prefractionation; protein identification; quantification;

    Abstract : ABSTRACT There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer?s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact with the extracellular fluid of the brain and is consequently a valuable medium for identifying biomarkers for neurological disorders. READ MORE

  4. 4. Amyloid β peptide: from monomer solubility to fibril structure

    Author : Veronica Lattanzi; NanoLund: Centre for Nanoscience; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer´s disease; Aβ solubility; small angle scattering; number of filaments; Aβ40; Aβ42 and Aβ42 S26Q ; fibril structure;

    Abstract : Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. READ MORE

  5. 5. Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin

    Author : Faisal Hayat Nazir; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; biomarker; neurogranin; APP; human iPSCs; CSF;

    Abstract : Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. READ MORE