Search for dissertations about: "Alzheimer s disease"

Showing result 1 - 5 of 79 swedish dissertations containing the words Alzheimer s disease.

2. 1. Clusterin in brain and cerebrospinal fluidin Alzheimer s disease

   Author : Anna-Maria Nilselid; Göteborgs universitet; []
   Keywords : Alzheimer s disease; clusterin; apolipoprotein J; SP-40; brain tissue; cerebrospinal fluid; glycosylation; biomarker; enzyme-linked immunosorbent assay;

   Abstract : The apolipoprotein clusterin is suggested to be involved in the pathogenesis of Alzheimer¡¦s disease (AD). At the start of these studies, results had indicated that clusterin was elevated in AD brain, compared with controls. READ MORE

4. 2. Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes

   Author : Sofia Söllvander; Lars Lannfelt; Anna Erlandsson; Frida Ekholm-Pettersson; Linda Söderberg; Pär Gellerfors; Martin Hallbeck; Uppsala universitet; []
   Keywords : Alzheimer s Disease; Amyloid-beta; Protofibrils; ELISA; ELISpot; Astrocyte; Monoclonal Antibody; Immunofluorescence; Medicinsk vetenskap; Medical Science;

   Abstract : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. READ MORE

5. 3. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

   Author : Kina Höglund; Göteborgs universitet; []
   Keywords : Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

   Abstract : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. READ MORE

6. 4. Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease

   Author : Annika Olsson; Göteborgs universitet; []
   Keywords : Alzheimer s disease; amyloid precursor protein; ß-amyloid; biomarker; cerebrospinal fluid; enzyme-linked immunosorbent assay; plasma;

   Abstract : Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). READ MORE

7. 5. Vascular dementia - classification and clinical correlates

   Author : Ulla Andin; Lund Psykiatri; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; psychosomatics; Psychiatry; clinical psychology; Medicine human and vertebrates ; falls; clinical course; hypertension; orthostatic hypotension; dizziness; cerebrovascular disease; Alzheimer?s disease; Neuropathological subgroups; cardiovascular disease; Psykiatri; klinisk psykologi; psykosomatik; Medicin människa och djur ;

   Abstract : During the period (1976-1995) a total of 175 consecutive patients (m 88/f 87) with neuropathologically verified vascular dementia (VaD) were examined. 22 patients with pure Alzheimer's Disease (AD) were also studied. All patients were diagnosed and followed at the Department of Psychogeriatrics (Lund University Hospital). READ MORE