Search for dissertations about: "Alzheimers sjukdom"

Showing result 16 - 20 of 59 swedish dissertations containing the words Alzheimers sjukdom.

2. 16. The Molecular Chaperone DNAJB6 - A Suppressor of Disease Related Amyloid Fibril Formation

   Author : Cecilia Månsson; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNAJ; HSP40; molecular chaperones; amyloid fibrils; Alzheimer’s disease; Huntington’s Disease; crosslinking mass spectrometry; chemical kinetics; aggregation; fibril formation;

   Abstract : Several neurodegenerative diseases are caused by peptides or proteins forming amyloid fibrils such as the Aβ peptide involved in Alzheimer’s disease and the huntingtin exon-1 with a prolonged polyglutamine (polyQ) stretch involved in Huntington’s disease. The ability to form amyloid fibrils is an intrinsic feature in all proteins. READ MORE

4. 17. Dementia Proteomics

   Author : Julia Remnestål; Peter Nilsson; Anna Månberg; Pieter Jelle Visser; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Proteomics; Alzheimer s disease; Frontotemporal dementia; Antibody array; Suspension bead array; Cerebrospinal fluid; Protein profiling; Biomarker discovery; Bioteknologi; Biotechnology;

   Abstract : The term dementia encompass a number of conditions arising as a consequence of tissue degeneration in the brain. This degeneration is caused by molecular events occurring on a cellular level including inflammation, defective waste disposal and accumulation of insoluble proteins and peptides. READ MORE

5. 18. Endoplasmic reticulum function in dendrites and dendritic spines of hippocampal neurons

   Author : Ai Na Ng; Sektion IV; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endoplasmic reticulum; primary culture; dendritic spines; live cell imaging; STIM1; carbachol; store-operated calcium entry; 3; familial Alzheimer s disease; 5-dihyroxyphenyglycine;

   Abstract : In the hippocampus, dendritic spines are compartmentalized postsynaptic micro-domains in the excitatory synapse. Subsets of bigger and mushroom-shaped hippocampal dendritic spines contain tubules and cisterns of endoplasmic reticulum (ER) that are connected to the soma and dendrites of the neuron. READ MORE

6. 19. Cardiac and vascular pathology in Lewy body disease and Alzheimer's disease: exploring neurocognitive disorder beyond the brain

   Author : Keivan Javanshiri; Lund Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The first aim of this thesis was to evaluate the prevalence of cardiovascular disease (CaVD), hypertension (HT), and type 2 diabetes mellitus (T2DM) in the neurodegenerative disorders Alzheimer’s disease (AD) and Lewy body disease (LBD). These conditions are considered modifiable risk factors for vascular dementia (VaD), and recent research has proposed its association with AD. READ MORE

7. 20. Vascular dementia - classification and clinical correlates

   Author : Ulla Andin; Lund Psykiatri; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; psychosomatics; Psychiatry; clinical psychology; Medicine human and vertebrates ; falls; clinical course; hypertension; orthostatic hypotension; dizziness; cerebrovascular disease; Alzheimer?s disease; Neuropathological subgroups; cardiovascular disease; Psykiatri; klinisk psykologi; psykosomatik; Medicin människa och djur ;

   Abstract : During the period (1976-1995) a total of 175 consecutive patients (m 88/f 87) with neuropathologically verified vascular dementia (VaD) were examined. 22 patients with pure Alzheimer's Disease (AD) were also studied. All patients were diagnosed and followed at the Department of Psychogeriatrics (Lund University Hospital). READ MORE