Search for dissertations about: "Aminoglycoside"

Showing result 16 - 20 of 27 swedish dissertations containing the word Aminoglycoside.

  2. 16. Antibiotic Resistance and the Cellular Currency S-adenosyl-methionine : Modification of aminoglycosides and nucleic acids

    Author : Sandesh Kanchugal P; Maria Selmer; Ditlev Brodersen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; streptomycin; spectinomycin; X-ray crystallography; methyltransferase; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Streptomycin and spectinomycin are antibiotics that bind to ribosomes and inhibit protein synthesis. Common resistance mechanisms involve enzymatic modification of the two drugs by aminoglycoside nucleotidyltransferases (ANTs). The first part of this thesis covers the structural mechanism of two ANT enzymes. READ MORE

  4. 17. Computational discovery of antibiotic resistance genes and their horizontal transfer

    Author : David Lund; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; phylogenetic analysis; Antibiotic resistance; horizontal gene transfer; computational screening;

    Abstract : Antibiotic resistance is increasing among clinical infections and represents one of the most serious threats to public health. Pathogens often become resistant by acquiring mobile antibiotic resistance genes (ARGs) via horizontal gene transfer (HGT). READ MORE

  5. 18. The diagnosis and protection of the auditory peripheral system

    Author : Mao Li Duan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cochlea; inner hair cell; outer hair cell; glutamate; post-synaptic receptor; auditory brainstem response; forward masking; noise trauma; hearing loss;

    Abstract : The main focus of this thesis is on the diagnosis and prevention of peripheral hearing loss. An auditory evoked response measure (forward masking) was developed that specifically tests the function of the inner hair cells, independently of the outer hair cells. READ MORE

  6. 19. The Mechanism of translation termination in Escherichia coli

    Author : David V. Freistroffer; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Protein synthesis in E. coli is terminated by the release factors (RFs) and the ribosome is prepared for another round of protein synthesis by ribosome recycling factor (RRF), elongation factor G (EF-G) and initiation factor (IF3). READ MORE

  7. 20. Determinants of peptidyl-tRNA drop-off from E. coli Ribosomes : Effects of antibiotics, mutations and translation factors

    Author : Reza Karimi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : During protein synthesis, some peptidyl-tRNA molecules dissociate from the ribosomes and become hydrolysed by peptidyl-tRNA hydrolase (Pth). Two different in vitro systems, poly(U) and natural mRNA programmed ribosomes, have been used in order to determine dissociation (drop-off) rates of deacylated- and peptidyl-tRNAs from different sites on ribosomes. READ MORE