Search for dissertations about: "Amirata Saei Dibavar"

Found 1 swedish dissertation containing the words Amirata Saei Dibavar.

2. 1. Molecular mechanisms and targets of new anticancer treatments

   Author : Amirata Saei Dibavar; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The work presented in this thesis is an effort to decipher and understand the mechanism of action (MOA) of anticancer agents by building on and complementing chemical proteomics methods. The backbone of the thesis relies on a recent method called Functional Identification of Target by Expression Proteomics (FITExP) developed in Zubarev lab, where drug induced proteomic signatures are analyzed in various cell lines and top differentially regulated proteins with consistent behavior are determined, among which the drug target and mechanistic proteins are usually present. READ MORE