Search for dissertations about: "Amyloid-beta"

Showing result 21 - 25 of 107 swedish dissertations containing the word Amyloid-beta.

  2. 21. Brain distribution of a bispecific antibody targeting Aβ

    Author : Gustavsson Tobias; Dag Sehlin; Stina Syvänen; Paul O'Callaghan; Danica Stanimirovic; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; blood-brain barrier; single-photon emission computed tomography SPECT ; bispecific antibody; immunotherapy; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

    Abstract : Alzheimer’s disease (AD) is characterised by aberrant protein aggregation in the brain with subsequent synaptic loss, neuroinflammation, and brain atrophy that ultimately clinically manifests as cognitive impairment. Histopathological findings in AD are extracellular plaques of the protein amyloid-beta (Aβ), Aβ in blood vessels (CAA), and intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau. READ MORE

  4. 22. Interplay between autophagy and amyloid beta metabolism in Alzheimer’s disease

    Author : Richeng Jiang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by two pathological hallmarks: extracellular amyloid-beta peptide (Aβ) plaque depositions and neurofibrillary tangles (NFTs) composed of intracellular hyperphosphorylated tau aggregations. A cellular degradation system, autophagy is additionally dysfunctional in AD and plays a key role in Aβ and tau metabolisms. READ MORE

  5. 23. To Fold or To Fibrillate? Serendipity in Stability Studies

    Author : Olga Szczepankiewicz; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein stability; protein reconstitution; protein aggregation; Monellin; PGB1; Split-GFP; Amyloid beta;

    Abstract : Proteins are complex structures and years of research have been spent on attempts to understand their complexity. The non-covalent interactions involved in protein folding are: hydrophobic effect, electrostatic interactions, van der Waals interactions and hydrogen bonding. READ MORE

  6. 24. Spectroscopic studies of dynorphin neuropeptides and the amyloid beta-peptide : The consequences of biomembrane interactions

    Author : Loïc Hugonin; Astrid Gräslund; Bernard Lebleu; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biophysics; biofysik;

    Abstract : Dynorphin A, dynorphin B and big dynorphin are endogenous opioid neuropeptides. They play an important role in a wide variety of physiological functions such as regulation of pain processing and memory acquisition. Such actions are generally mediated through the κ-receptors. READ MORE

  7. 25. Synthesis of Ring-fused Peptidomimetics : Interacting with Amyloid Fibrils

    Author : Dan E. Adolfsson; Fredrik Almqvist; Anna Linusson; Morten Grötli; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; synthesis; peptidomimetics; thiazoline fused 2-pyridones; Alzheimer s disease; Parkinson s disease; Amyloid; Amyloid-beta; alfa-Synuclein; method development; organisk kemi; Organic Chemistry;

    Abstract : Parkinson's and Alzheimer's disease are the two most common neurological disorders in humans. Both conditions involve progressive death of neurons in the central nervous system, decline in bodily functions and eventually (and invariably), death. So far, no cure exists and the available treatments can only ease symptoms. READ MORE