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Showing result 1 - 5 of 8 swedish dissertations matching the above criteria.

  2. 1. ASPECTS OF FLUID THERAPY: An experimental study of the effects of systemic inflammation, microvascular permeability, blood pressure and plasma volume

    Author : Maris Dubniks; Anestesiologi och intensivvård; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; activated protein C; SIRS; albumin; blood pressure; colloids; plasma volume; hypervolaemia; hypovolaemia; microcirculation; noradrenalin; permeability; prostacyclin;

    Abstract : Adequate circulating blood volume is a prerequisite for circulatory stability. Fluid therapy aims at correcting hypovolaemia, and is an important part of the haemodynamic management of perioperative and critically ill patients. READ MORE

  4. 2. Development of Proteochemometrics—A New Approach for Analysis of Protein-Ligand Interactions

    Author : Maris Lapins; Jarl Wikberg; Johan Gottfries; Uppsala universitet; []
    Keywords : Pharmaceutical pharmacology; chemometrics; QSAR; G-protein coupled receptors; Melanocortin receptors; protein-ligand interactions; Farmaceutisk farmakologi;

    Abstract : A new approach to analysis of protein-ligand interactions, termed proteochemometrics, has been developed. Contrary to traditional quantitative structure-activity relationship (QSAR) methods that aim to correlate a description of ligands to their interactions with one particular target protein, proteochemometrics considers many targets simultaneously. READ MORE

  5. 3. Engineering and applications of surface displayed tyrosinase on Escherichia coli

    Author : David Hörnström; Antonius J. A. van Maris; Joachim José; KTH; []
    Keywords : Bioteknologi; Biotechnology;

    Abstract : The rise of biotechnology has provided a toolbox to deal with major challenges related to pollution and health. Microbial enzymes constitute powerful macromolecules with applications in environmental technology, and industrial and medical production. READ MORE

  6. 4. Metabolic engineering and cultivation strategies for recombinant production of (R)-3-hydroxybutyrate

    Author : Mariel Perez-Zabaleta; Gen Larsson; Antonius J. A. van Maris; Diethard Mattanovich; KTH; []
    Keywords : Escherichia coli; R -3-hydroxybutyrate; nitrogen limitation; nitrogen depletion; lignocellulose; fed batch; acetate; β-ketothiolase; acetoacetyl-CoA reductase; Halomonas boliviensis.; Bioteknologi; Biotechnology;

    Abstract : Metabolic engineering and process engineering are two powerful disciplines to design and improve microbial processes for sustainable production of an extensive number of compounds ranging from chemicals to pharmaceuticals. The aim of this thesis was to synergistically combine these two disciplines to improve the production of a model chemical called (R)-3-hydroxybutyrate (3HB), which is a medium-value product with a stereocenter and two functional groups. READ MORE

  7. 5. Methods development for metaproteomics-guided bioprospecting of novel enzymes

    Author : Jutta Speda; Martin Karlsson; Nalle Jonsson; Antonius Van Maris; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Industrial biotechnology has been announced by several organizations and governments as a key enabling technology for the enhanced economic growth in a low-carbon and knowledge-based bioeconomy. An important goal to promote an environment friendly and sustainable industrial biotechnology is the discovery of new enzymes. READ MORE