Search for dissertations about: "Anaphylaxis"

Showing result 6 - 10 of 18 swedish dissertations containing the word Anaphylaxis.

  2. 6. Role of mast cell-derived mediators for leukocyte / endothelium-interactions and microvascular mechanisms in inflammation and in anaphylaxis

    Author : Yancai Guo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Anaphylaxis; histamine; intravital microscopy; leukocyte; mast cell-deficient rat Ws Ws ; microdialysis;

    Abstract : The overall objective of this thesis was to study the roles of mast cell-derived mediators for leukocyte/endothelium interactions and microvascular mechanisms in inflammation and in anaphylaxis, using mast cell-deficient Ws/Ws rats and their wild-type +/+ littermates. The efflux of endogenous histamine and edema formation evoked by subplantar injection of compound 48/80 in rat hind-paws was dose-dependent in +/+ rats, and was essentially lacking in Ws/Ws rats. READ MORE

  4. 7. Severe reactions to foods in childhood : clinical perspectives, epidemiology and risk management

    Author : Mirja Vetander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Food allergy is a public health issue, particularly among children, and seems to be increasing worldwide. Allergic reactions to foods vary in terms of symptoms and severity. Anaphylaxis, the most severe allergic reaction, can be fatal. Food allergy has significant negative impact in the daily lives of allergic children and their families. READ MORE

  5. 8. Immunoregulation in an experimental model of allergic asthma

    Author : Magnus Korsgren; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allergic asthma; macrophage migration inhibitory factor; eosinophils; gd T cells; NK1.1 T cells; natural killer cells; immunoglobulins; B cells; innate immunity; allergic airway inflammation; immediate hypersensitivity; Physiology; Fysiologi; Immunology; serology; transplantation; Immunologi; serologi;

    Abstract : In allergic asthma the immune response to antigen is inappropriate, leading to an inflammatory process in the respiratory mucosa. To further elucidate immunological mechanisms involved in the development of such inflammation, control mice and mice deficient in selected cell types or proteins, were used in experimental models of allergic asthma and anaphylaxis. READ MORE

  6. 9. Leukotriene C4 synthase : studies on oligomerization and subcellular localization

    Author : Jesper Svartz; Mats Söderström; Sven Hammarström; Colin Funk; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Leukotrienes (LTs) are polyunsaturated fatty acid derivatives formed by oxygenation of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. Upon activation of inflammatory cells 5-LO is translocated to the nuclear envelope where it converts arachidonic acid to the unstable epoxide LTA4. READ MORE

  7. 10. Mechanisms triggering the recruitment of mast cell progenitors to the lung and regulation of mast cell degranulation

    Author : Behdad Zarnegar; Jenny Hallgren; Madeleine Rådinger; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mast cells; Mast cell progenitors; Recruitment; Lung; Virus; Influenza; Innate immunity; Poly I:C; IL-33; VAAT; SLC10A4; Degranulation;

    Abstract : Mast cells stem from the bone marrow and migrate via the blood as mast cell progenitors. Upon arrival in peripheral tissues, they develop into mast cells. These rare immune cells have numerous granules that contain large amounts of pro-inflammatory mediators. READ MORE