Search for dissertations about: "Anaplastic Lymphoma Kinase"

Showing result 1 - 5 of 18 swedish dissertations containing the words Anaplastic Lymphoma Kinase.

2. 1. Anaplastic Lymphoma Kinase mutations and downstream signalling

   Author : Christina Schönherr; Ruth H Palmer; Aristidis Moustakas; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anaplastic Lymphoma Kinase; oncogene; RTK; neuroblastoma; crizotinib; NVP-TAE684; gain-of-function; MYCN; transcription factor; small GTPase; Rap1; C3G; PC12 cells; neurite outgrowth; molecular cell biology; molekylär cellbiologi;

   Abstract : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. READ MORE

4. 2. Exploiting Drosophila as a model system for studying anaplastic lymphoma kinase in vivo

   Author : Therese Eriksson; Ruth Palmer; Stefan Thor; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; Receptor tyrosine kinase; Jeb; neuroblastoma; actin polymerization; Wasp; Scar; Vrp1; Arp2 3; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and an oncogene associated with several human diseases, but its normal function in humans and other vertebrates is unclear. Drosophila melanogaster has an ALK homolog, demonstrating that the RTK has been conserved throughout evolution. READ MORE

5. 3. Investigating the function of Anaplastic Lymphoma Kinase

   Author : Emma Vernersson Lindahl; Bengt Hallberg; Ruth Palmer; Göran Roos; Carina Hellberg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALK; nervous system; knockout; development; Jelly-Belly; Pathology; Patologi;

   Abstract : Anaplastic Lymphoma Kinase (ALK) was discovered in 1994, as a chromosomal translocation, t(2;5)(p23;q35), often seen in Anaplastic Large Cell Lymphomas (ALCL). Since then ALK has been extensively studied in this disease as well as in different model organisms. READ MORE

6. 4. Mechanistic Implications and Characterization of Anaplastic Lymphoma Kinase (ALK) mutations in Neuroblastoma

   Author : Damini Chand; Bengt Hallberg; Christer Larsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; ALK; crizotinib; receptor tyrosine kinase; molekylärbiologi; Molecular Biology;

   Abstract : Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion partner of nucleophosmin in Anaplastic large cell lymphoma in 1994. ALK is involved in myriad of cancers including neuroblastoma which is the most common extracranial solid tumor affecting young children. READ MORE

7. 5. Epidemiological and clinical aspects of T-cell lymphoma

   Author : Henrik Cederleuf; Medicinsk onkologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; population-based; peripheral T-cell lymphoma; Anaplastic large cell lymphoma; angioimmunoblastic; elderly; ASCT; comorbidity; prognostic factors; follow-up; limited stage; etoposide; CHOP; overall survival; radiotherapy;

   Abstract : T-cell lymphoma (TCL) is a rare group of malignancies and one of the important aims in this thesis has been to broaden the general knowledge of TCL with descriptive patient data. Main focus has been to examine prognosticfactors for overall survival (OS) and progression-free survival (PFS), and to evaluate different treatment approaches and follow-up (FU) after treatment. READ MORE