Search for dissertations about: "Anaplastic thyroid cancer"

Showing result 1 - 5 of 9 swedish dissertations containing the words Anaplastic thyroid cancer.

  2. 1. Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma

    Author : Naveen Ravi; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic thyroid cancer; copy number alterations; somatic mutations; mutational signatures; DNA methylation analysis; Gene expression analysis;

    Abstract : Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. READ MORE

  4. 2. Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells

    Author : Camilla Ingeson-Carlsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thyroid; cancer; NIS; MAPK; PI3K; BRAFV600E; migration; 3D culture;

    Abstract : Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter (NIS) expression and impaired iodide uptake in tumor cells. READ MORE

  5. 3. Molecular genetic studies of human thyroid tumors

    Author : Tony Frisk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Follicular thyroid tumors; tumor progression; Cowden disease; PTEN; CGH; RET; medullary thyroid carcinoma; MEN 2; anaplastic carcinoma.;

    Abstract : Tumors of the thyroid gland are common among the general population, but only a small proportion is malignant. The vast majority of thyroid tumors are benign, so called follicular adenomas. Sometimes subtypes such as atypical adenomas and adenomas with oxyphil, i.e. READ MORE

  6. 4. Behind the scenes of thyroid tumors : underlying genetic mechanisms

    Author : Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

    Abstract : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). READ MORE

  7. 5. Basic and translational studies of follicular thyroid neoplasia

    Author : Theodoros Foukakis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Follicular thyroid cancer; follicular thyroid adenoma; PAX8-PPARgamma; PPARgamma; PTEN; RAS; RASSF1A; NORE1A; TERT; quantitative RT-PCR; microarray; cancer biomarker;

    Abstract : Thyroid tumors occur frequently in the general population and although the majority represents benign follicular adenomas (FTA), thyroid cancer constitutes 1% of all malignancies worldwide. Among the differentiated cancers, three main types are recognized, including the papillary and follicular forms (PTC and FTC) that originate from the follicular thyrocytes, and the medullary carcinoma that arises from the C-cells. READ MORE