Search for dissertations about: "Anders S. Byström"

Showing result 1 - 5 of 6 swedish dissertations containing the words Anders S. Byström.

  2. 1. Functional aspects of wobble uridine modifications in yeast tRNA

    Author : Anders Esberg; Anders Byström; James T. Anderson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Transfer RNA; Modified nucleosides; Elongator complex; Translation; Kluyveromyces lactis γ-toxin; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Transfer RNAs (tRNA) function as adaptor molecules in the translation of mRNA into protein. These adaptor molecules require modifications of a subset of their nucleosides for optimal function. The most frequently modified nucleoside in tRNA is position 34 (wobble position), and especially uridines present at this position. READ MORE

  4. 2. Functional aspects of modified nucleosides in tRNA

    Author : Hao Xu; Anders S. Byström; Damien Hermand; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; tRNA modification; frameshifting; Elongator complex; Elp1p; Prb1p; proteolysis; glioma; TRM6 61; PKCα;

    Abstract : Transfer ribonucleic acids (tRNAs) are extensively modified, especially their anticodon loops. Modifications at position 34 (wobble base) and 37 in these loops affect the tRNAs’ decoding ability, while modifications outside the anticodon loops, e.g. m1A58 of tRNAMeti, may be crucial for tRNA structure or stability. READ MORE

  5. 3. Investigation of RNase P active site residues and catalytic domain interaction

    Author : Guanzhong Mao; Leif Kirsebom; Roland Hartmann; Britt-marie Sjöberg; Anders Byström; Anthony Forster; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNase P; Ribozyme; PRORP; Induced fit model; RNase P-pre-tRNA interaction; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : RNase P is an essential endoribonuclease responsible for the maturation of the tRNA 5’end. The RNase P family encompasses the ribozyme based, RNase P RNP, and proteinaceous RNase P (PRORP). The ribozyme based RNase P is widely distributed in most species while PRORP has so far mainly been found in some eukaryotic cells. READ MORE

  6. 4. Physiological consequences of Elongator complex inactivation in Eukaryotes

    Author : Tony Karlsborn; Anders Byström; Hans Ronne; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Elongator complex; wobble uridine modifications; IKBKAP; IKAP; Familial dysautonomia; Untargeted Metabolic profiling.; molekylärbiologi; Molecular Biology;

    Abstract : Mutations found in genes encoding human Elongator complex subunits have been linked to neurodevelopmental disorders such as familial dysautonomia (FD), rolandic epilepsy and amyotrophic lateral sclerosis. In addition, loss-of-function mutations in genes encoding Elongator complex subunits cause defects in neurodevelopment and reduced neuronal function in both mice and nematodes. READ MORE

  7. 5. The Kluyveromyces lactis killer toxin is a transfer RNA endonuclease

    Author : Jian Lu; Anders Byström; Leif Kirsebom; Umeå universitet; []
    Keywords : Molecular biology; K. lactis γ-toxin; tRNA endonuclease; modified nucleosides; 5-methoxycarbonylmethyl-2-thiouridine; 5-methylaminomethyl-2-thiouridine; anticodon stem loop; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Killer strains of the yeast Kluyveromyces lactis secrete a heterotrimeric protein toxin (zymocin) to inhibit the growth of sensitive yeasts. The cytotoxicity of zymocin resides in the γ subunit (γ-toxin), however the mechanism of cytotoxicity caused by γ-toxin was previously unknown. READ MORE