Search for dissertations about: "Anders Sjöstedt"

Showing result 6 - 10 of 15 swedish dissertations containing the words Anders Sjöstedt.

  2. 6. Reactive oxygen and nitrogen in host defence against Francisella tularensis

    Author : Helena Lindgren; Anders Sjöstedt; Tommy Sundquist; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Francisella tularensis; inducible nitric oxide synthase; phagocyte oxidase; macrophages; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; klinisk bakteriologi; Clinical Bacteriology;

    Abstract : Francisella tularensis, the causative agent of tularemia, is a potent human and animal pathogen. Initially upon infection of the host, intramacrophage proliferation of F. tularensis occurs but after activation of the acquired host immunity, the phagocytes become activated to kill the bacterium. In my thesis, I focused on mechanisms utilized by F. READ MORE

  4. 7. Characterization of the attenuated Francisella tularensis strain FSC043 : with special focus on the gene pdpC

    Author : Marie Lindgren; Anders Sjöstedt; Marina Santic; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; intracellular bacteria; J774; apoptosis; pyroptosis; PdpC; FSC043; Clinical Bacteriology; klinisk bakteriologi; mikrobiologi; Microbiology;

    Abstract : Francisella tularensis is a highly infective, intracellular bacterium. It is capable of infecting a wide range of mammals and causes the disease tularemia in humans. As a result of its high infectivity there have been a lot of efforts made to create a generally available vaccine against this pathogen. READ MORE

  5. 8. Environmental factors selecting for predation resistant and potentially pathogenic bacteria in aquatic environments

    Author : Peter Mathisen; Agneta Andersson; Johanna Thelaus; Mats Forsman; Anders Sjöstedt; Tron Frede Thingstad; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Eutrophication; productivity; predation pressure; predation-resistant bacteria; pathogens; Francisella tularensis; adaptation; biomarker; oligotyping;

    Abstract : The long history of co-existence of bacteria and their protozoan predators in aquatic environments has led to evolution of protozoa resistant bacteria (PRB). Many of these bacteria are also pathogenic to humans. READ MORE

  6. 9. The Francisella pathogenicity island : its role in type VI secretion and intracellular infection

    Author : Lena Meyer; Anders Sjöstedt; Siobhan C. Cowley; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella; FPI; Type VI Secretion; Igl; DotU; VgrG; Pdp; microinjection; phagosomal escape; intracellular replication; Clinical Bacteriology; klinisk bakteriologi;

    Abstract : Intracellular bacteria have developed various mechanisms to enter and persist in host cells and, at the same time, to evade the host immune response. One such pathogen is Francisella tularensis, the etiological agent of tularemia. READ MORE

  7. 10. Determining the role of guanylate-binding proteins for host defense against Francisella tularensis

    Author : Nasibeh Mohammadi; Anders Sjöstedt; Wolfgang P. Schröder; Anetta S. Härtlova; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Guanylate-binding proteins; bone marrow-derived macrophages; IFN-γ activation; cytokine patterns; inflammasome pathways; co-infection; mouse co-culture model; Biochemistry; biokemi; immunologi; Immunology; mikrobiologi; Microbiology; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar;

    Abstract : Francisella tularensis is a highly virulent, intracellular bacterium and the causative agent of the human disease tularemia. This is a zoonotic, often vector-borne disease. Due to its intracellular nature, F. READ MORE