Search for dissertations about: "Andreas Mårtensson"

Found 5 swedish dissertations containing the words Andreas Mårtensson.

2. 1. PCR adjusted cure rates in clinical trials of antimalarial drugs in Africa : influence of extended follow-up and consecutive day blood sampling

   Author : Andreas Mårtensson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Malaria treatment guidelines are based primarily on results from clinical trials. Accurate assessment of drug efficacy in such studies therefore represents a prerequisite to ensure effective and lifesaving treatment for children with Plasmodium falciparum infections in Africa. READ MORE

4. 2. Antibiotic use among children in low- and middle-income countries : Studies on global trends, and contextual determinants of antibiotic prescribing in Eastern Uganda

   Author : Gbemisola Allwell-Brown; Emily White Johansson; Andreas Mårtensson; Freddy Kitutu; Laith Hussain-Alkhateeb; Susanne Strömdahl; Mike English; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotic; child; low- and middle-income countries; LMICs; fever; under-five; Uganda; primary healthcare; health systems; Social Medicine; Socialmedicin; International Health; Internationell hälsa; Epidemiologi; Epidemiology; Family Medicine; Allmänmedicin; Pediatrik; Pediatrics;

   Abstract : This thesis aimed to systematically map trends in reported antibiotic use (RAU) among sick under-five children across low- and middle-income countries (LMICs) in 2005-2017, and, to understand the contextual determinants of antibiotic prescribing in Eastern Uganda. Based on 132 national surveys from 73 LMICs, and using Bayesian linear regression models, trends in RAU among sick under-five children (with symptoms of fever, diarrhoea or cough with fast/difficult breathing) across LMICs in 2005-2017 were mapped by WHO region, World Bank country income group, symptom complaint (Study-I), and by the following user characteristics: rural/urban residence, maternal education, household wealth and source of care (Study-II). READ MORE

5. 3. Unresolved Controversies in Child Pneumonia in low and middle income Countries

   Author : Nick Brown; Andreas Mårtensson; Mats Målqvist; Stephen Allen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Paediatrics; pneumonia; global health; antibiotics; poverty; risk scoring; Pediatrik; Pediatrics; Epidemiologi; Epidemiology;

   Abstract : There has been a fall globally in pneumonia-related fatality in children during the Millennium Development and early Sustainable Development Goal era.However, pneumonia remains the single largest contributor to mortality with issues including antibiotic resistance, pollution, a change in infective epidemiology, equipoise over effects of adjunctive treatments and identification of sick, decompensating children. READ MORE

6. 4. Evaluating and optimizing surveillance and response strategies for malaria elimination in the Asia Pacific region

   Author : Chris Cotter; Andreas Mårtensson; Arantxa Roca-Feltrer; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; malaria elimination; surveillance and response; reactive case detection; sociobehavorial; reactive drug administration; molecular diagnostics; microsatellite genotyping; Plasmodium vivax; low transmission;

   Abstract : Malaria case investigation and reactive case detection (RACD) activities are widely implemented in low transmission settings to identify additional malaria infections and gather surveillance information, but with varying degrees of success. Challenges in conducting RACD include poor diagnostic sensitivity (particularly for low density and asymptomatic infections), knowledge gaps among those conducting RACD, financial and resource constraints, and operational and logistical difficulties. READ MORE

7. 5. New strategies and tools for Plasmodium falciparum case management and surveillance in the era of imminent resistance to artemisinin-based combination therapy in Tanzania

   Author : Lwidiko E Mhamilawa; Andreas Mårtensson; Billy Ngasala; Ulrika Morris; Ib Christian Bygbjerg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malaria; Plasmodium falciparum; artemether-lumefantrine; drug resistance; Tanzania; Medicinsk vetenskap; Medical Science;

   Abstract : Artemether-lumefantrine has been an efficacious first line treatment for uncomplicated Plasmodium falciparum malaria in Tanzania since its introduction in 2006. Interest has developed in understanding the observation of high residual PCR determined positivity rates on day 3 after supervised artemether-lumefantrine treatment in the magnitude of almost 30% in previous assessments from 2015 in Bagamoyo district, Tanzania. READ MORE