Search for dissertations about: "Andrei Chabes"

Found 5 swedish dissertations containing the words Andrei Chabes.

  2. 1. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity

    Author : Robert Buckland; Andrei Chabes; Juan Méndez; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Replication Fidelity; Mutations; dNTP pools; Mismatch Repair; Checkpoint; Ribonucleotide Reductase; Msh2; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Abstract : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. READ MORE

  4. 2. dNTPs : the alphabet of life

    Author : Dinesh Kumar; Andrei Chabes; Britt-Marie Sjöberg; Umeå universitet; []
    Keywords : ribonucleotide reductase; dNTP pools; s-phase checkpoint; mutagenesis; medicinsk biokemi; Medical Biochemistry;

    Abstract : From microscopic bacteria to the giant whale, every single living organism on Earth uses the same language of life: DNA. Deoxyribonucleoside triphosphates––dNTPs (dATP, dTTP, dGTP, and dCTP)––are the building blocks of DNA and are therefore the “alphabet of life”. READ MORE

  5. 3. Pathology of dNTP dysregulation

    Author : Phong Tran; Andrei Chabes; Erik Johansson; Ola Hammarsten; Umeå universitet; []
    Keywords : dNTP metabolism; DNA replication; mutation rate; cancer; heart development; RNR; SAMHD1; Rrm1; Samhd1; medicinsk biokemi; Medical Biochemistry;

    Abstract : Deoxyribonucleoside triphosphates (dNTPs) are precursors for DNA replication and repair. Mammalian cells have two distinct biosynthesis pathways to supply dNTPs: de novo and salvage pathways. READ MORE

  6. 4. Regulation of ribonucleotide reductase and the role of dNTP pools in genomic stability in yeast Saccharomyces cerevisiae

    Author : Olga Tsaponina; Andrei Chabes; Ola Hammarsten; Umeå universitet; []
    Keywords : ribonucleotide reductase; dNTP; genome stability;

    Abstract : Every living organism is programmed to reproduce and to pass genetic information to descendants. The information has to be carefully copied and accurately transferred to the next generation.  Therefore organisms have developed the network of conserved mechanisms to survey the protection and precise transfer of the genetic information. READ MORE

  7. 5. Mechanisms controlling DNA damage survival and mutation rates in budding yeast

    Author : Jörgen Wiberg; Andrei Chabes; Per Sunnerhagen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dNTPs; ribonucleotide reductase; translesion synthesis; TLS polymerases; medicinsk biokemi; Medical Biochemistry;

    Abstract : All living organisms are made of cells, within which genetic information is stored on long strands of deoxyribonucleic acid (DNA). The DNA encodes thousands of different genes and provides the blueprint for all of the structures and activities occurring within the cell. READ MORE